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Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in Experimental Autoimmune Encephalomyelitis

Citation

Miranda-Hernandez, S and Gerlach, N and Fletcher, JM and Biros, E and Mack, M and Korner, H and Baxter, AG, Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in Experimental Autoimmune Encephalomyelitis, Journal of Immunology, 187, (2) pp. 791-804. ISSN 0022-1767 (2011) [Refereed Article]


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Copyright Statement

Copyright © 2011 The American Association of Immunologists, Inc. All rights reserved

DOI: doi:10.4049/jimmunol.1001992

Abstract

The potential roles of TLRs in the cause and pathogenesis of autoimmune CNS inflammation remain contentious. In this study, we examined the effects of targeted deletions of TLR1, TLR2, TLR4, TLR6, TLR9, and MyD88 on the induction of myelin oligodendrocyte glycoprotein 35–55 (MOG35–55) peptide/CFA/pertussis toxin-induced autoimmune encephalomyelitis. Although C57BL/6. Tlr12/2, C57BL/6.Tlr42/2 and C57BL/6.Tlr62/2 mice showed normal susceptibility to disease, signs were alleviated in female C57BL/6.Tlr22/2 and C57BL/6.Tlr92/2 mice and C57BL/6.Tlr2/92/2 mice of both sexes. C57BL/6.Myd882/2 mice were completely protected. Lower clinical scores were associated with reduced leukocyte infiltrates. These results were confirmed by passive adoptive transfer of disease into female C57BL/6.Tlr22/2 and C57BL/6.Tlr92/2 mice, where protection in the absence of TLR2 was associated with fewer infiltrating CD4+ cells in the CNS, reduced prevalence of detectable circulating IL-6, and increased proportions of central (CD62L+) CD4+CD25+Foxp3+ regulatory T cells. These results provide a potential molecular mechanism for the observed effects of TLR signaling on the severity of autoimmune CNS inflammation.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Korner, H (Professor Heinrich Korner)
ID Code:72456
Year Published:2011
Web of Science® Times Cited:38
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-08-26
Last Modified:2017-11-07
Downloads:0

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