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Cartilage proteomics: Challenges, solutions and recent advances
Citation
Wilson, R and Bateman, JF, Cartilage proteomics: Challenges, solutions and recent advances, Proteomics Clinical Applications , 2, (2) pp. 251-263. ISSN 1862-8346 (2008) [Refereed Article]
DOI: doi:10.1002/prca.200780007
Abstract
The mammalian skeleton is largely composed of cartilage and bone. The major functions of cartilage are first to provide a transient template for development of the axial and appendicular skeleton and secondly to provide permanent articulating joint surfaces. The unique cartilage extracellular matrix (ECM) is essential for the load-bearing and viscoelastic properties of cartilage tissues. Maintained by the chondrocytes, the ECM contains a myriad of proteins and proteoglycans organized into precise networks. Many cartilage disorders result from genetic disruption of cartilage ECM components, their interactions and/or degradation. Although technically challenging, the proteomic analysis of cartilage in development and disease is now emerging as a clinically important research area. In this article, we will review progress in the proteomic characterization of cartilage-related samples.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the health sciences |
UTAS Author: | Wilson, R (Dr Richard Wilson) |
ID Code: | 72411 |
Year Published: | 2008 |
Web of Science® Times Cited: | 6 |
Deposited By: | Central Science Laboratory |
Deposited On: | 2011-08-26 |
Last Modified: | 2021-02-18 |
Downloads: | 0 |
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