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Cartilage proteomics: Challenges, solutions and recent advances

Citation

Wilson, RR and Bateman, JF, Cartilage proteomics: Challenges, solutions and recent advances, Proteomics - Clinical Applications , 2, (2) pp. 251-263. ISSN 1862-8346 (2008) [Refereed Article]

DOI: doi:10.1002/prca.200780007

Abstract

The mammalian skeleton is largely composed of cartilage and bone. The major functions of cartilage are first to provide a transient template for development of the axial and appendicular skeleton and secondly to provide permanent articulating joint surfaces. The unique cartilage extracellular matrix (ECM) is essential for the load-bearing and viscoelastic properties of cartilage tissues. Maintained by the chondrocytes, the ECM contains a myriad of proteins and proteoglycans organized into precise networks. Many cartilage disorders result from genetic disruption of cartilage ECM components, their interactions and/or degradation. Although technically challenging, the proteomic analysis of cartilage in development and disease is now emerging as a clinically important research area. In this article, we will review progress in the proteomic characterization of cartilage-related samples.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Wilson, RR (Dr Richard Wilson)
ID Code:72411
Year Published:2008
Web of Science® Times Cited:5
Deposited By:Central Science Laboratory
Deposited On:2011-08-26
Last Modified:2012-02-20
Downloads:0

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