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Neurophysiologically-based mean-field modelling of tonic cortical activity in post-traumatic stress disorder (PTSD), schizophrenia, first episode schizophrenia and attention deficit hyperactivity disorder (ADHD)

Citation

Rowe, DL and Robinson, PA and Rennie, CJ and Harris, AW and Felmingham, KL and Lazzaro, I and Gordon, E, Neurophysiologically-based mean-field modelling of tonic cortical activity in post-traumatic stress disorder (PTSD), schizophrenia, first episode schizophrenia and attention deficit hyperactivity disorder (ADHD), Journal of Integrative Neuroscience, 3, (4) pp. 453-487. ISSN 0219-6352 (2004) [Refereed Article]

DOI: doi:10.1142/S0219635204000592

Abstract

A recently developed quantitative model of cortical activity is used that permits data comparison with experiment using a quantitative and standardized means. The model incorporates properties of neurophysiology including axonal transmission delays, synapto-dendritic rates, range-dependent connectivities, excitatory and inhibitory neural populations, and intrathalamic, intracortical, corticocortical and corticothalamic pathways. This study tests the ability of the model to determine unique physiological properties in a number of different data sets varying in mean age and pathology. The model is used to fit individual electroencephalographic (EEG) spectra from post-traumatic stress disorder (PTSD), schizophrenia, first episode schizophrenia (FESz), attention deficit hyperactivity disorder (ADHD), and their age/sex matched controls. The results demonstrate that the model is able to distinguish each group in terms of a unique cluster of abnormal parameter deviations. The abnormal physiology inferred from these parameters is also consistent with known theoretical and experimental findings from each disorder. The model is also found to be sensitive to the effects of medication in the schizophrenia and FESz group, further supporting the validity of the model.

Item Details

Item Type:Refereed Article
Keywords:Thalamocortical; thalamic reticular nucleus; arousal; neuron; pruning; synapse; EEG
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:72394
Year Published:2004
Deposited By:Psychology
Deposited On:2011-08-25
Last Modified:2011-11-08
Downloads:0

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