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Developing an Integrated Brain, Behavior and Biological Response Profile in Posttraumatic Stress Disorder (PTSD)


Falconer, EM and Felmingham, KL and Allen, A and Clark, CR and McFarlane, AC and Williams, LM and Bryant, RA, Developing an Integrated Brain, Behavior and Biological Response Profile in Posttraumatic Stress Disorder (PTSD), Journal of Integrative Neuroscience, 7, (3) pp. 439-456. ISSN 0219-6352 (2008) [Refereed Article]

DOI: doi:10.1142/S0219635208001885


The present study sought to determine a profile of integrated behavioral, brain and autonomic alterations in PTSD. Previous findings suggest that PTSD is associated with changes across electrophysiological (EEG and ERP), autonomic and cognitive/behavioral measures. In particular, PTSD has been associated with reduced cognitive performance, altered cortical arousal (measured by EEG), diminished late ERP component to oddball task targets (reduced P3 amplitude) and increased autonomic arousal relative to healthy controls. The present study examined measures of cognitive function, auditory oddball ERP components, autonomic function (heart rate and skin conductance) and EEG during resting conditions in 44 individuals with PTSD and 44 non-trauma-exposed controls, and predicted that an integrated profile of changes across a number of these measures would show a high level of sensitivity and specificity in discriminating PTSD from controls. Nine variables showing strongly significant (p < 0.002) between-group differences were entered into a discriminant function analysis. Four of these measures successfully discriminated the PTSD and non-PTSD groups: change in tonic arousal, duration of attention switching, working memory reaction time and errors of commission during visuospatial maze learning. Tonic arousal change contributed the most variance in predicting group membership. These results extend previous findings and provide an integrated biomarker profile that characterizes both PTSD and non-PTSD groups with a high degree of sensitivity and specificity. This outcome provides a platform for future studies to test how this profile of disturbances in autonomic and information processing may be unique to PTSD or may occur generically across clinical and/or other anxiety disorders.

Item Details

Item Type:Refereed Article
Keywords:Posttraumatic stress disorder; sensitivity; specificity; information processing; autonomic; behavior; cognition; electrophysiology; integration
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:72391
Year Published:2008
Deposited By:Psychology
Deposited On:2011-08-25
Last Modified:2014-11-27

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