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Mapping frontal-limbic correlates of orienting to change detection


Williams, LM and Felmingham, KL and Kemp, AH and Rennie, C and Brown, K and Bryant, RA and Gordon, E, Mapping frontal-limbic correlates of orienting to change detection, Neuroreport, 18, (3) pp. 197-202. ISSN 0959-4965 (2007) [Refereed Article]

DOI: doi:10.1097/WNR.0b013e328010ff80


Orienting responses are elicited by salient stimuli, and may be indexed by skin conductance responses. Concurrent functional magnetic resonance imaging and skin conductance response recording was used to identify neural correlates of orienting to abrupt sensory change (infrequent high pitch oddball 'target' tones embedded in frequent lower pitch 'standard' tones) in 16 healthy participants. 'With skin conductance response' responses to targets were distinguished by preferentially greater activity in the amygdala and ventral medial and lateral frontal cortical regions. By contrast, 'without skin conductance response' responses elicited distinctive activity in the dorsal lateral frontal cortex and supramarginal gyrus. These findings suggest that orienting to unexpected sensory change elicits a network for appraising salience and novelty, whereas, in the absence of orienting, a parallel network for sensory and context evaluation is preferentially engaged.

Item Details

Item Type:Refereed Article
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:72371
Year Published:2007
Web of Science® Times Cited:24
Deposited By:Psychology
Deposited On:2011-08-25
Last Modified:2011-08-25

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