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Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: Synthesis of 3-pyrrolines and 2-alkylpyrroles


You, HT and Grosse, AC and Howard, JK and Hyland, CJT and Just, J and Molesworth, PP and Smith, JA, Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: Synthesis of 3-pyrrolines and 2-alkylpyrroles, Organic & Biomolecular Chemistry, 9, (10) pp. 3948-3953. ISSN 1477-0520 (2011) [Refereed Article]

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Copyright Statement

Copyright 2011 The Royal Society of Chemistry

DOI: doi:10.1039/c1ob05111c


The partial reduction of pyrroles is not a common practice even though it offers a potential route to pyrroline building blocks, commonly used for synthesis. We have investigated the reduction of 2-acyl-N-sulfonylpyrroles and by varying the hydride source and solvent, achieved a chemoselective reduction, leading to 3-pyrrolines and alkyl pyrroles in high yield.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Organic chemistry
Research Field:Organic chemical synthesis
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:You, HT (Mr Hai You)
UTAS Author:Grosse, AC (Mr Andrew Grosse)
UTAS Author:Howard, JK (Mr James Howard)
UTAS Author:Hyland, CJT (Dr Chris Hyland)
UTAS Author:Just, J (Mr Jeremy Just)
UTAS Author:Molesworth, PP (Dr Peter Molesworth)
UTAS Author:Smith, JA (Associate Professor Jason Smith)
ID Code:72273
Year Published:2011
Web of Science® Times Cited:12
Deposited By:Chemistry
Deposited On:2011-08-24
Last Modified:2012-06-14

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