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Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: Synthesis of 3-pyrrolines and 2-alkylpyrroles

journal contribution
posted on 2023-05-17, 07:35 authored by You, HT, Grosse, AC, Howard, JK, Hyland, CJT, Just, J, Molesworth, PP, Jason SmithJason Smith
The partial reduction of pyrroles is not a common practice even though it offers a potential route to pyrroline building blocks, commonly used for synthesis. We have investigated the reduction of 2-acyl-N-sulfonylpyrroles and by varying the hydride source and solvent, achieved a chemoselective reduction, leading to 3-pyrrolines and alkyl pyrroles in high yield.

Funding

University of Tasmania

History

Publication title

Organic & Biomolecular Chemistry

Volume

9

Issue

10

Pagination

3948-3953

ISSN

1477-0520

Department/School

School of Natural Sciences

Publisher

Royal Society of Chemistry

Place of publication

Thomas Graham House, Science Park, Milton Rd, Cambridge, England, Cambs, Cb4 0Wf

Rights statement

Copyright 2011 The Royal Society of Chemistry

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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