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Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies

Citation

Yadav, PN and Beveridge, RE and Blay, J and Boyd, AR and Chojnacka, MW and Decken, A and Deshpande, AA and Gardiner, MG and Hambley, TW and Hughes, MJ and Jolly, L and Lavangie, JA and MacInnis, TD and McFarland, SA and New, EJ and Gossage, RA, Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies, MedChemComm, 2, (4) pp. 274-277. ISSN 2040-2503 (2011) [Refereed Article]


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Copyright Statement

Copyright 2011 The Royal Society of Chemistry

DOI: doi:10.1039/c0md00211a

Abstract

The syntheses, characterisation and biological activities (IC(50); DNA binding) of four mononuclear Pt oxazoline complexes are reported. These materials are the compounds cis-[PtCl(2)(NH(3))(Etox-kappa(I)N)] (1: Etox = 2-ethyl-2-oxazoline), [PtCl(2)(anilox-kappa(2)N,N')] (2: anilox = 4,4-dimethyl-2-[o-anilinyl]-2-oxazoline), cis-[PtCl(2)(Etox-kappa(I)N)(2)] (3) and [PtCl(pyox-kappa(3)N,N',N')] (4: pyoxH = pyridine-2-carboxyanil-[o-{4,4-dimethyl-2-oxazolinyl}-ide]) and all four are shown to have slightly lower cytotoxicities in vitro when compared to cisplatin against the A2780 ovarian cancer cell line. These new materials all appear to be bio-active via the formation of DNA adducts. Complexes 1 and 2 have been further characterised in the solid-state by X-ray diffraction methods.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Inorganic Chemistry
Research Field:Bioinorganic Chemistry
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Gardiner, MG (Associate Professor Michael Gardiner)
Author:Gossage, RA (Professor Robert Gossage)
ID Code:72167
Year Published:2011
Web of Science® Times Cited:11
Deposited By:Chemistry
Deposited On:2011-08-23
Last Modified:2017-10-25
Downloads:0

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