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Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies
Citation
Yadav, PN and Beveridge, RE and Blay, J and Boyd, AR and Chojnacka, MW and Decken, A and Deshpande, AA and Gardiner, MG and Hambley, TW and Hughes, MJ and Jolly, L and Lavangie, JA and MacInnis, TD and McFarland, SA and New, EJ and Gossage, RA, Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies, MedChemComm, 2, (4) pp. 274-277. ISSN 2040-2503 (2011) [Refereed Article]
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Copyright Statement
Copyright 2011 The Royal Society of Chemistry
Abstract
The syntheses, characterisation and biological activities (IC(50); DNA binding) of four mononuclear Pt oxazoline complexes are reported. These materials are the compounds cis-[PtCl(2)(NH(3))(Etox-kappa(I)N)] (1: Etox = 2-ethyl-2-oxazoline), [PtCl(2)(anilox-kappa(2)N,N')] (2: anilox = 4,4-dimethyl-2-[o-anilinyl]-2-oxazoline), cis-[PtCl(2)(Etox-kappa(I)N)(2)] (3) and [PtCl(pyox-kappa(3)N,N',N')] (4: pyoxH = pyridine-2-carboxyanil-[o-{4,4-dimethyl-2-oxazolinyl}-ide]) and all four are shown to have slightly lower cytotoxicities in vitro when compared to cisplatin against the A2780 ovarian cancer cell line. These new materials all appear to be bio-active via the formation of DNA adducts. Complexes 1 and 2 have been further characterised in the solid-state by X-ray diffraction methods.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Chemical Sciences |
| Research Group: | Inorganic chemistry |
| Research Field: | Bioinorganic chemistry |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Gardiner, MG (Associate Professor Michael Gardiner) |
| UTAS Author: | Gossage, RA (Professor Robert Gossage) |
| ID Code: | 72167 |
| Year Published: | 2011 |
| Web of Science® Times Cited: | 15 |
| Deposited By: | Chemistry |
| Deposited On: | 2011-08-23 |
| Last Modified: | 2017-10-25 |
| Downloads: | 0 |
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