Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies

The syntheses, characterisation and biological activities (IC(50); DNA binding) of four mononuclear Pt oxazoline complexes are reported. These materials are the compounds cis-[PtCl(2)(NH(3))(Etox-kappa(I)N)] (1: Etox = 2-ethyl-2-oxazoline), [PtCl(2)(anilox-kappa(2)N,N')] (2: anilox = 4,4-dimethyl-2-[o-anilinyl]-2-oxazoline), cis-[PtCl(2)(Etox-kappa(I)N)(2)] (3) and [PtCl(pyox-kappa(3)N,N',N')] (4: pyoxH = pyridine-2-carboxyanil-[o-{4,4-dimethyl-2-oxazolinyl}-ide]) and all four are shown to have slightly lower cytotoxicities in vitro when compared to cisplatin against the A2780 ovarian cancer cell line. These new materials all appear to be bio-active via the formation of DNA adducts. Complexes 1 and 2 have been further characterised in the solid-state by X-ray diffraction methods.