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Individual and Joint Action of Environmental Factors and Risk of MS


Van der Mei, IAF and Simpson Jr, S and Stankovich, J and Taylor, BV, Individual and Joint Action of Environmental Factors and Risk of MS, Neurologic Clinics , 29, (2) pp. 233-255. (2011) [Substantial Review]

DOI: doi:10.1016/j.ncl.2010.12.007


This review discusses the leading environmental and lifestyle factors suspected to play a role in the onset of multiple sclerosis (MS). The authors utilize the framework of the Rothman Causal Pie Model1 to discuss the joint action, or interaction, of different factors that that may be causally involved in MS. A key feature of many environmental exposures is that the period of life in which exposure occurs and possibly the timing of a sequence of events can affect how they mediate their effects. Evidence on the timing of each environmental factor is discussed.

Item Details

Item Type:Substantial Review
Research Division:Health Sciences
Research Group:Epidemiology
Research Field:Epidemiology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Van der Mei, IAF (Professor Ingrid van der Mei)
UTAS Author:Simpson Jr, S (Dr Steve Simpson JR)
UTAS Author:Stankovich, J (Dr Jim Stankovich)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
ID Code:72142
Year Published:2011
Web of Science® Times Cited:46
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-08-23
Last Modified:2011-08-23

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