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Neural Networks of Information Processing in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study

Citation

Bryant, RA and Felmingham, KL and Kemp, AH and Barton, M and Peduto, A and Rennie, C and Gordon, E and Williams, LM, Neural Networks of Information Processing in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study, Biological Psychiatry: A Journal of Psychiatric Research, 58, (2) pp. 111-118. ISSN 0006-3223 (2005) [Refereed Article]


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Copyright Statement

Copyright 2005 The definitive version is available at http://www.sciencedirect.com

DOI: doi:10.1016/j.biopsych.2005.03.021

Abstract

Background: Neuroimaging studies report reduced medial prefrontal cortical (particularly anterior cingulate) but enhanced amygdala response to fear signals in posttraumatic Stress Disorder (PTSD). We investigated whether anterior cingulate-amygdala dysregulation in PTSD would generalize to salient, but nonthreat related signals. Methods: Individuals with PTSD (n  14) and age and sex-matched nontraumatized controls (n  14) completed an auditory oddball paradigm adapted to functional magnetic resonance imaging at a 1.5-T field strength. Results: Controls displayed bilateral activation in ventral anterior cingulate and amygdala networks, and PTSD subjects showed bilateral dorsal anterior cingulate and amygdala activation to targets relative to nontargets. Compared to controls, PTSD subjects showed enhanced responses to targets in the dorsal and rostral anterior cingulate, and left amygdala. Whole-brain analyses confirmed the expected pattern of distributed prefrontal-parietal responses to targets in the oddball task. Greater activity in posterior parietal somatosensory regions was observed in PTSD. Conclusions: Our findings of enhanced anterior cingulate responses in PTSD contrast with reports of reduced activity for threat stimuli, suggesting that the latter may be specific to processing of threat-related content. Activation in rostral and dorsal anterior cingulate, left amygdala and posterior parietal networks in response to salient, nonthreatening stimuli may reflect generalized hypervigilance.

Item Details

Item Type:Refereed Article
Keywords:Posttraumatic stress disorder, fMRI, information processing,
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:72141
Year Published:2005
Web of Science® Times Cited:112
Deposited By:Psychology
Deposited On:2011-08-23
Last Modified:2011-09-13
Downloads:1 View Download Statistics

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