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Neural Networks of Information Processing in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study
Citation
Bryant, RA and Felmingham, KL and Kemp, AH and Barton, M and Peduto, A and Rennie, C and Gordon, E and Williams, LM, Neural Networks of Information Processing in Posttraumatic Stress Disorder: A Functional Magnetic Resonance Imaging Study, Biological Psychiatry: A Journal of Psychiatric Research, 58, (2) pp. 111-118. ISSN 0006-3223 (2005) [Refereed Article]
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Copyright Statement
Copyright © 2005 The definitive version is available at http://www.sciencedirect.com
DOI: doi:10.1016/j.biopsych.2005.03.021
Abstract
Background: Neuroimaging studies report reduced medial prefrontal cortical (particularly anterior cingulate) but enhanced
amygdala response to fear signals in posttraumatic Stress Disorder (PTSD). We investigated whether anterior cingulate-amygdala
dysregulation in PTSD would generalize to salient, but nonthreat related signals.
Methods: Individuals with PTSD (n = 14) and age and sex-matched nontraumatized controls (n = 14) completed an auditory
oddball paradigm adapted to functional magnetic resonance imaging at a 1.5-T field strength.
Results: Controls displayed bilateral activation in ventral anterior cingulate and amygdala networks, and PTSD subjects showed
bilateral dorsal anterior cingulate and amygdala activation to targets relative to nontargets. Compared to controls, PTSD subjects
showed enhanced responses to targets in the dorsal and rostral anterior cingulate, and left amygdala. Whole-brain analyses confirmed
the expected pattern of distributed prefrontal-parietal responses to targets in the oddball task. Greater activity in posterior parietal
somatosensory regions was observed in PTSD.
Conclusions: Our findings of enhanced anterior cingulate responses in PTSD contrast with reports of reduced activity for threat
stimuli, suggesting that the latter may be specific to processing of threat-related content. Activation in rostral and dorsal anterior
cingulate, left amygdala and posterior parietal networks in response to salient, nonthreatening stimuli may reflect generalized
hypervigilance.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Posttraumatic stress disorder, fMRI, information processing, |
| Research Division: | Psychology |
| Research Group: | Biological psychology |
| Research Field: | Behavioural neuroscience |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Felmingham, KL (Professor Kim Felmingham) |
| ID Code: | 72141 |
| Year Published: | 2005 |
| Web of Science® Times Cited: | 154 |
| Deposited By: | Psychology |
| Deposited On: | 2011-08-23 |
| Last Modified: | 2022-08-24 |
| Downloads: | 1 View Download Statistics |
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