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Influence of comorbid depression on fear in posttraumatic stress disorder: An fMRI study


Kemp, AH and Felmingham, KL and Das, P and Hughes, G and Peduto, A and Bryant, RA and Williams, LM, Influence of comorbid depression on fear in posttraumatic stress disorder: An fMRI study, Psychiatry Research: Neuroimaging Section, 155, (3) pp. 265-269. ISSN 0925-4927 (2007) [Refereed Article]

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Copyright © 2007 Elsevier Ireland Ltd. The definitive version is available at

DOI: doi:10.1016/j.pscychresns.2007.01.010


Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal–amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.

Item Details

Item Type:Refereed Article
Keywords:PTSD; Depression; Comorbidity
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
UTAS Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:72132
Year Published:2007
Web of Science® Times Cited:32
Deposited By:Psychology
Deposited On:2011-08-22
Last Modified:2011-09-15

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