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Enhanced Amygdala and Medial Prefrontal Activation During Nonconscious Processing of Fear in Posttraumatic Stress Disorder: An fMRI Study

Citation

Bryant, RA and Kemp, AH and Felmingham, KL and Liddell, B and Olivieri, G and Peduto, A and Gordon, E and Williams, LM, Enhanced Amygdala and Medial Prefrontal Activation During Nonconscious Processing of Fear in Posttraumatic Stress Disorder: An fMRI Study, Human Brain Mapping, 29, (5) pp. 517-523. ISSN 1065-9471 (2008) [Refereed Article]


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Copyright Statement

Copyright © 2007 Wiley-Liss, Inc. The definitive published version is available online at: http://onlinelibrary.wiley.com/

DOI: doi:10.1002/hbm.20415

Abstract

Abstract: Biological models of posttraumatic stress disorder (PTSD) suggest that patients will display heightened amygdala but decreased medial prefrontal activity during processing of fear stimuli. However, a rapid and automatic alerting mechanism for responding to nonconscious signals of fear suggests that PTSD may display heightened rather than decreased MPFC under nonconscious processing of fear stimuli. This study used functional magnetic resonance imaging to examine blood oxygenation level-dependent signal changes during nonconscious presentation (16.7 ms, masked) of fearful and neutral faces in 15 participants with PTSD and 15 age and sex-matched healthy control participants. Results indicate that PTSD participants display increased amygdala and MPFC activity during nonconscious processing of fearful faces. These data extend existing models by suggesting that the impaired MPFC activation in PTSD may be limited to conscious fear processing.

Item Details

Item Type:Refereed Article
Keywords:fMRI; medial prefrontal cortex; amygdala; posttraumatic stress disorder; fear
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:72128
Year Published:2008
Web of Science® Times Cited:114
Deposited By:Psychology
Deposited On:2011-08-22
Last Modified:2014-12-03
Downloads:5 View Download Statistics

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