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Tissue factor pathway inhibitor: New insights into an old inhibitor


Adams, M, Tissue factor pathway inhibitor: New insights into an old inhibitor, Seminars in Thrombosis and Hemostasis, 38, (2) pp. 129-134. ISSN 0094-6176 (2012) [Refereed Article]

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Copyright Statement

Copyright 2012 by Thieme Medical Publishers, Inc.,

DOI: doi:10.1055/s-0032-1301410


Blood coagulation in vivo is triggered by the tissue factor (TF) pathway. The major physiological regulator of this pathway is tissue factor pathway inhibitor (TFPI), a Kunitz-type inhibitor that regulates the activity of the TF-factor VIIa complex in a factor Xa-dependent manner, thus controlling the generation of thrombin and ultimately, fibrin. Although some of the in vivo and in vitro effects of TFPI have been described for nearly a century, the bulk of the research that has elucidated the physiology of this inhibitor has only occurred in the past 25 years. Despite this, many questions remain. This review will highlight the recent advances in knowledge related to TFPI, with an emphasis on new insights into its physiology, association with disease, and possible use as a therapeutic anticoagulant.

Item Details

Item Type:Refereed Article
Keywords:tissue factor, tissue factor pathway inhibitor, thrombosis, protein S, platelets
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Adams, M (Dr Murray Adams)
ID Code:72094
Year Published:2012
Web of Science® Times Cited:16
Deposited By:Health Sciences A
Deposited On:2011-08-22
Last Modified:2017-11-02

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