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Separation of nucleic acid precursors on an amphoteric surfactant modified monolith using combined eluent flow, pH and concentration gradient

Citation

Nesterenko, EP and Guivarc'h, C and Duffy, C and Paull, B, Separation of nucleic acid precursors on an amphoteric surfactant modified monolith using combined eluent flow, pH and concentration gradient, Journal of Separation Science, 30, (17) pp. 2910-2916. ISSN 1615-9306 (2007) [Refereed Article]

DOI: doi:10.1002/jssc.200700355

Abstract

An RP monolithic column coated with an amphoteric carboxybetaine type surfactant has been used with a combined triple eluent concentration, pH and flow gradient ion chromatography technique for the simultaneous separation of up to 18 nucleotides, nucleosides and nucleobases. The separation of up to eight precursors on a 1 cm long monolithic microcolumn using the combined gradient approach is also shown. The method was applied to the separation of the above nucleic acid precursors in perchloric acid extracts of yeastolates samples. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Paull, B (Professor Brett Paull)
ID Code:72003
Year Published:2007
Web of Science® Times Cited:5
Deposited By:Research Division
Deposited On:2011-08-18
Last Modified:2011-08-18
Downloads:0

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