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Decreased virulence of cystic fibrosis Pseudomonas aeruginosa in Dictyostelium discoideum


Bradbury, RS and Reid, DWEC and Inglis, TJJ and Champion, AC, Decreased virulence of cystic fibrosis Pseudomonas aeruginosa in Dictyostelium discoideum, Microbiology and Immunology, 55, (4) pp. 224-230. ISSN 0385-5600 (2011) [Refereed Article]

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Copyright 2011 The Societies and Blackwell Publishing Asia P/L The definitive published version is available online at:

DOI: doi:10.1111/j.1348-0421.2011.00314.x


The characteristics of clinical and environmental isolates of Pseudomonas aeruginosa from both hospital and community settings were analyzed in a eukaryotic virulence model employing the AX2 and X22 mutants of Dictyostelium discoideum. Thirty-one strains, including two Australian epidemic strains, of P. aeruginosa were analyzed, five from environmental sources, six from clinical sources other than cystic fibrosis (CF) patients and nineteen from CF patients' respiratory secretions. The majority of CF isolates almost uniquely supported the growth of D. discoideum. CF isolates of P. aeruginosa were found to be less virulent than isolates from other sources. Varying degrees of inhibition of the developmental cycle of D. discoideum when growing on CF isolates were also noted. This is the first description of P. aeruginosa isolates from clinical and environmental sources supporting the growth of D. discoideum.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Medical microbiology
Research Field:Medical bacteriology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Bradbury, RS (Dr Richard Bradbury)
UTAS Author:Reid, DWEC (Dr David Reid)
UTAS Author:Champion, AC (Dr Alan Champion)
ID Code:72001
Year Published:2011
Web of Science® Times Cited:11
Deposited By:Medicine
Deposited On:2011-08-18
Last Modified:2014-11-25
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