eCite Digital Repository
Anterior cingulate activity to salient stimuli is modulated by autonomic arousal in Posttraumatic Stress Disorder
Citation
Felmingham, KL and Williams, LM and Kemp, AH and Rennie, C and Gordon, E and Bryant, RA, Anterior cingulate activity to salient stimuli is modulated by autonomic arousal in Posttraumatic Stress Disorder, Psychiatry Research: Neuroimaging , 2009, (173) pp. 59-62. ISSN 0925-4927 (2009) [Refereed Article]
![]() | PDF Restricted - Request a copy 288Kb |
Copyright Statement
The definitive version is available at http://www.sciencedirect.com
DOI: doi:10.1016/j.pscychresns.2008.12.005
Abstract
Reduced ventral anterior cingulate (vACC) activity to threat is thought to reflect an impairment in regulating
arousal networks in posttraumatic stress disorder (PTSD). Concurrent functional magnetic resonance imaging
(fMRI) and skin conductance response (SCR) recording were used to examine neural functioning when arousal
networks are engaged. Eleven participants with PTSD and 11 age- and sex-matched non-traumatized controls
performed an oddball task that required responding to salient, non-trauma-related auditory target tones
embedded in lower frequency background tones. Averaged target-background analyses revealed significantly
greater dorsal ACC, supramarginal gyrus, and hippocampal activity in PTSD relative to control participants.With-
SCR target responses resulted in increased vACC activity in controls, and dorsal ACC activity in PTSD. PTSD
participants had reduced vACC activity relative to controls to target toneswhen SCR responseswere present. This
reduction in vACC in PTSD relative to controlswas not apparent inwithout-SCR responses. These findings suggest
that a reduction in vACC in PTSD occurs specifically when arousal networks are engaged.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Functional MRI; Skin conductance responses; Oddball; Anterior cingulate; PTSD; Arousal |
Research Division: | Psychology |
Research Group: | Biological psychology |
Research Field: | Behavioural neuroscience |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Felmingham, KL (Professor Kim Felmingham) |
ID Code: | 71974 |
Year Published: | 2009 |
Web of Science® Times Cited: | 51 |
Deposited By: | Psychology |
Deposited On: | 2011-08-17 |
Last Modified: | 2014-11-27 |
Downloads: | 0 |
Repository Staff Only: item control page