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Anterior cingulate activity to salient stimuli is modulated by autonomic arousal in Posttraumatic Stress Disorder

journal contribution
posted on 2023-05-17, 07:11 authored by Kim FelminghamKim Felmingham, Williams, LM, Kemp, AH, Rennie, C, Gordon, E, Bryant, RA
Reduced ventral anterior cingulate (vACC) activity to threat is thought to reflect an impairment in regulating arousal networks in posttraumatic stress disorder (PTSD). Concurrent functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) recording were used to examine neural functioning when arousal networks are engaged. Eleven participants with PTSD and 11 age- and sex-matched non-traumatized controls performed an oddball task that required responding to salient, non-trauma-related auditory target tones embedded in lower frequency background tones. Averaged target-background analyses revealed significantly greater dorsal ACC, supramarginal gyrus, and hippocampal activity in PTSD relative to control participants.With- SCR target responses resulted in increased vACC activity in controls, and dorsal ACC activity in PTSD. PTSD participants had reduced vACC activity relative to controls to target toneswhen SCR responseswere present. This reduction in vACC in PTSD relative to controlswas not apparent inwithout-SCR responses. These findings suggest that a reduction in vACC in PTSD occurs specifically when arousal networks are engaged.

History

Publication title

Psychiatry Research: Neuroimaging

Volume

2009

Issue

173

Pagination

59-62

ISSN

0925-4927

Department/School

School of Psychological Sciences

Publisher

Elsevier Sci Ireland Ltd

Place of publication

Customer Relations Manager, Bay 15, Shannon Industrial Estate Co, Clare, Ireland

Rights statement

The definitive version is available at http://www.sciencedirect.com

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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