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Duration of posttraumatic stress disorder predicts hippocampal grey matter loss


Felmingham, KL and Williams, LM and Whitford, TJ and Falconer, E and Kemp, AH and Peduto, A and Bryant, RA, Duration of posttraumatic stress disorder predicts hippocampal grey matter loss, Neuroreport, 20, (16) pp. 1402-1406. ISSN 0959-4965 (2009) [Refereed Article]

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Copyright © 2009 Lippincott Williams & Wilkins

DOI: doi:10.1097/WNR.0b013e3283300fbc


To examine the impact of environmental stress on grey matter volume in posttraumatic stress disorder (PTSD), we investigated the relationship between duration of PTSD and grey matter volume of hippocampus and anterior cingulate cortex. Twenty-one participants with PTSD and 17 trauma-exposed controls, matched for age and sex and with no history of substance dependence, underwent a T1-weighted structural MRI scan and voxel-based morphometry was employed. After controlling for age, depression and whole-brain volume, analysis of covariance revealed significant reductions in hippocampus and rostral anterior cingulate cortex in PTSD, and there was a significant negative correlation between right hippocampal volume and PTSD duration. This pattern suggests that prolonged PTSD may have cumulative adverse effects on hippocampal volume, highlighting the potential role of genetic–environmental interactions.

Item Details

Item Type:Refereed Article
Keywords:anterior cingulate cortex, grey matter volume, hippocampus,
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:71969
Year Published:2009
Web of Science® Times Cited:61
Deposited By:Psychology
Deposited On:2011-08-17
Last Modified:2014-12-03
Downloads:3 View Download Statistics

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