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Preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in Posttraumatic Stress Disorder

Citation

Bryant, RA and Felmingham, KL and Falconer, EM and Benito, LP and Dobson Stone, C and Pierce, KD and Schofield, PR, Preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in Posttraumatic Stress Disorder, Biological Psychiatry: A Journal of Psychiatric Research, 67, (12) pp. 1217-1219. ISSN 0006-3223 (2010) [Refereed Article]


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Copyright Statement

Copyright 2010 Society of Biological Psychiatry The definitive version is available at http://www.sciencedirect.com

DOI: doi:10.1016/j.biopsych.2010.03.016

Abstract

Objective: This study was intended to assess the extent to which the low-expression alleles of the serotonin transporter gene promoter predict poor response to cognitive behavior therapy in patients with posttraumatic stress disorder (PTSD). Method: Forty-five patients with PTSD underwent an 8-week exposure-based cognitive behavior therapy program and provided mouth swabs or saliva samples to extract genomic DNA and classify individuals according to four allelic forms (SA, SG, LA, LG) of the 5-HTT-linked polymorphic region (5-HTTLPR). We determined whether the 5-HTTLPR genotype predicted change in PTSD severity following treatment (n  45) and 6 months later (n  42). Results: After controlling for pretreatment PTSD severity and number of treatment sessions, the 5-HTTLPR low-expression genotype group (S or LG allele carriers) displayed more severe PTSD 6 months following treatment relative to other patients. Conclusions: This study suggests a genetic contribution to treatment outcome following cognitive behavior therapy and implicates the serotonergic system in response to exposure-based treatments in PTSD.

Item Details

Item Type:Refereed Article
Keywords:Cognitive behavior therapy, genetics, posttraumatic
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Health, Clinical and Counselling Psychology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Felmingham, KL (Professor Kim Felmingham)
ID Code:71910
Year Published:2010
Web of Science® Times Cited:66
Deposited By:Psychology
Deposited On:2011-08-15
Last Modified:2014-11-27
Downloads:3 View Download Statistics

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