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Preliminary evidence of the short allele of the serotonin transporter gene predicting poor response to cognitive behavior therapy in Posttraumatic Stress Disorder
journal contribution
posted on 2023-05-17, 07:07 authored by Bryant, RA, Kim FelminghamKim Felmingham, Falconer, EM, Benito, LP, Dobson Stone, C, Pierce, KD, Schofield, PRObjective: This study was intended to assess the extent to which the low-expression alleles of the serotonin transporter gene promoter predict poor response to cognitive behavior therapy in patients with posttraumatic stress disorder (PTSD). Method: Forty-five patients with PTSD underwent an 8-week exposure-based cognitive behavior therapy program and provided mouth swabs or saliva samples to extract genomic DNA and classify individuals according to four allelic forms (SA, SG, LA, LG) of the 5-HTT-linked polymorphic region (5-HTTLPR). We determined whether the 5-HTTLPR genotype predicted change in PTSD severity following treatment (n = 45) and 6 months later (n = 42). Results: After controlling for pretreatment PTSD severity and number of treatment sessions, the 5-HTTLPR low-expression genotype group (S or LG allele carriers) displayed more severe PTSD 6 months following treatment relative to other patients. Conclusions: This study suggests a genetic contribution to treatment outcome following cognitive behavior therapy and implicates the serotonergic system in response to exposure-based treatments in PTSD.
History
Publication title
Biological Psychiatry: A Journal of Psychiatric ResearchVolume
67Issue
12Pagination
1217-1219ISSN
0006-3223Department/School
School of Psychological SciencesPublisher
Elsevier Science IncPlace of publication
360 Park Ave South, New York, USA, Ny, 10010-1710Rights statement
Copyright © 2010 Society of Biological Psychiatry The definitive version is available at http://www.sciencedirect.comRepository Status
- Restricted