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The approach-withdrawal and valence-arousal models highlight that specific brain laterality profiles may distinguish depression and anxiety. However, studies remain to be conducted in multiple clinical populations that directly test the diagnostic specificity of these hypotheses. The current study compared electroencephalographic data under resting state, eyes closed conditions in patients with major depressive disorder(MDD)(N= 15) and post-traumatic stress disorder (PTSD) (N= 14) relative to healthy controls (N= 15) to examine the specificity of brain laterality in these disorders. Key findings included (1) reduced left-frontal activity in MDD, (2) a positive correlation between PTSD severity and right-frontal lateralisation, (3) greater activity in PTSD patients relative to MDD within the right-parietotemporal region, and (4) globally increased alpha power in MDD. Findings partially support the diagnostic applicability of the theoretical frameworks. Future studies may benefit from examining task-driven differences between groups.

Item Type:	Refereed Article
Keywords:	Depression, MDD, Post-traumatic stress disorder, PTSD, Electroencephalography, EEG, Alpha asymmetry, Resting state, BRAINnet, Brain Resuorce International Database
Research Division:	Psychology
Research Group:	Biological psychology
Research Field:	Behavioural neuroscience
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Felmingham, KL (Professor Kim Felmingham)
ID Code:	71905
Year Published:	2010
Web of Science® Times Cited:	126
Deposited By:	Psychology
Deposited On:	2011-08-12
Last Modified:	2014-11-27
Downloads:	7 View Download Statistics