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The Amyloid Protein Precursor of Alzheimer's Disease Is a Mediator of the Effects of Nerve Growth Factor on Neurite Outgrowth

Citation

Milward, EA and Papadopoulos, R and Fuller, SJ and Moir, RD and Small, D and Beyreuther, K and Masters, CL, The Amyloid Protein Precursor of Alzheimer's Disease Is a Mediator of the Effects of Nerve Growth Factor on Neurite Outgrowth, Neuron, 9 pp. 129-137. ISSN 0896-6273 (1992) [Refereed Article]

Abstract

The (3A4 protein, the major component of the amyloid deposition characterizing Alzheimer’s disease, derives from the amyloid protein precursor (APP), an integral membrane protein with soluble derivatives. The function of APP is unknown. Both soluble and membraneassociated human brain APP (lo-‘0 M) significantly increased (P < 0.025) neurite length and branching in pheochromocytoma PC12 cells, but did not affect the number of neurites per cell. At higher concentrations, APP was cytotoxic, with a half-maximal concentration of 5 x 10mq M. Nerve growth factor (NGF) is known to affect APP expression in vivo and in vitro. Antibodies to APP specifically diminished the effects of NCF on neurite length and branching. Thus APP may act to mediate neurite outgrowth promotion by NGF.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Small, D (Professor David Small)
ID Code:71706
Year Published:1992
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-08-02
Last Modified:2011-08-02
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