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Evaluation of monolithic and sub 2 µm particle packed columns for the rapid screening for illicit drugs - application to the determination of drug contamination on Irish euro banknotes

Citation

Bones, J and Macka, M and Paull, B, Evaluation of monolithic and sub 2 µm particle packed columns for the rapid screening for illicit drugs - application to the determination of drug contamination on Irish euro banknotes, The Analyst, 132, (3) pp. 208-217. ISSN 0003-2654 (2007) [Refereed Article]

DOI: doi:10.1039/b615669j

Abstract

A study comparing recently available 100 x 3 mm id, 200 x 3 mm id monolithic reversed-phase columns with a 50 x 2.1 mm id, 1.8 mu m particle packed reversed-phase columns was carried out to determine the most efficient approach (using traditional van Deemter analysis and a modern kinetic plot approach) for the rapid screening of samples for 16 illicit drugs and associated metabolites. A plot of column backpressure versus plate number (N) showed a significant advantage of using the monolithic phases, with the 20 cm monolithic column exhibiting a maximum 15 000 plates at a column backpressure of approximate to 70 bar, compared to approximate to 7000 plates at 150 bar for the 5 cm 1.8 mm particle packed column. Optimum linear velocities were found to be 0.40 mm s(-1), 0.52 mm s(-1) and 0.98 mm s(-1) for the three above columns, respectively. The 20 cm monolithic column was subsequently applied to the separation and determination of illicit drug contamination on Irish euro banknotes, using methanol extraction followed by LC-MS/MS. Method performance data showed that the new LC-MS/MS method was significantly more sensitive than previous GC-MS/MS based methods for this application, with detection limits in the pg note(-1) region, based upon a 20 mu L standard injection. All of the notes examined tested positive for trace quantities of cocaine, with benzoylecgonine detected on 12 of the 45 notes sampled. Traces of heroin were also detected on three of the 45 notes.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Macka, M (Professor Mirek Macka)
Author:Paull, B (Professor Brett Paull)
ID Code:71617
Year Published:2007
Web of Science® Times Cited:22
Deposited By:Research Division
Deposited On:2011-07-25
Last Modified:2011-08-18
Downloads:0

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