University of Tasmania
Browse

File(s) under permanent embargo

Longitudinal Associations of Adiposity With Adult Lung Function in the Childhood Determinants of Adult Health (CDAH) Study

journal contribution
posted on 2023-05-17, 06:54 authored by Curry, BA, Christopher BlizzardChristopher Blizzard, Schmidt, MD, Eugene WaltersEugene Walters, Dwyer, T, Alison VennAlison Venn
Childhood BMI has been reported to be positively associated with adult lung function. The aim of this study was to investigate the effect of childhood BMI on young adult lung function independently of the effects of lean body mass (LBM). Clinical and questionnaire data were collected from 654 young Australian adults (aged 27–36 years), first studied when age 9, 12, or 15 years. Adult lung function was measured by forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC ratio, and the forced expiratory flow in the middle 50% of FVC (FEF25–75). BMI and LBM were derived from anthropometric measures at baseline (1985) and at follow-up (2004–2006). Multivariable models were used to investigate the effect of age and sex standardized BMI in childhood on adult lung function, before and after adjustment for LBM. Adult adiposity had a strong deleterious effect on lung function, irrespective of childhood BMI, and adjustment for childhood LBM eliminated any apparent beneficial effect of childhood BMI on adult FEV1 or FVC. This suggests that the beneficial effect of increased BMI in childhood on adult FEV1 and FVC observed in previous longitudinal studies is likely to be attributable to greater childhood LBM not adiposity. Obese children who become obese adults can expect to have poorer lung function than those who maintain healthy weight but large deficits in lung function are also likely for healthy weight children who become obese adults. This highlights the importance of lifetime healthy weight maintenance.

History

Publication title

Obesity

Volume

19

Issue

10

Pagination

2069-2075

ISSN

1930-7381

Department/School

Menzies Institute for Medical Research

Publisher

Nature Publishing Group

Place of publication

United States

Rights statement

Copyright © 2011 Nature Publishing Group

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC