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Anticipation in familial hematologic malignancies

Citation

Tegg, EM and Thomson, RJ and Stankovich, JM and Banks, A and Marsden, KA and Lowenthal, RM and Foote, SJ and Dickinson, JL, Anticipation in familial hematologic malignancies, Blood, 117, (4) pp. 1308-1310. ISSN 0006-4971 (2011) [Refereed Article]


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Copyright Statement

Copyright ©2011 American Society of Hematology

Official URL: http://www.hematology.org/About-ASH/Terms.aspx

DOI: doi:10.1182/blood-2010-07-296475

Abstract

We describe a collection of 11 families with > 2 generations of family members whose condition has been diagnosed as a hematologic malignancy. In 9 of these families there was a significant decrease in age at diagnosis in each subsequent generation (anticipation). The mean age at diagnosis in the first generation was 67.8 years, 57.1 years in the second, and 41.8 years in the third (P < .0002). This was confirmed in both direct parentoffspring pairs with a mean reduction of 19 years in the age at diagnosis (P  .0087) and when the analysis was repeated only including cases of mature B-cell neoplasm (P  .0007). We believe that these families provide further insight into the nature of the underlying genetic mechanism of predisposition in these families.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Tegg, EM (Dr Elizabeth Tegg)
Author:Thomson, RJ (Dr Russell Thomson)
Author:Stankovich, JM (Dr Jim Stankovich)
Author:Banks, A (Mrs Annette Banks)
Author:Marsden, KA (Dr Katherine Marsden)
Author:Lowenthal, RM (Professor Ray Lowenthal)
Author:Foote, SJ (Professor Simon Foote)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
ID Code:71238
Year Published:2011
Web of Science® Times Cited:7
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-07-12
Last Modified:2012-03-20
Downloads:0

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