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Anticipation in familial hematologic malignancies


Tegg, EM and Thomson, RJ and Stankovich, JM and Banks, A and Marsden, KA and Lowenthal, RM and Foote, SJ and Dickinson, JL, Anticipation in familial hematologic malignancies, Blood, 117, (4) pp. 1308-1310. ISSN 0006-4971 (2011) [Refereed Article]

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Copyright Statement

Copyright ©2011 American Society of Hematology

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DOI: doi:10.1182/blood-2010-07-296475


We describe a collection of 11 families with > 2 generations of family members whose condition has been diagnosed as a hematologic malignancy. In 9 of these families there was a significant decrease in age at diagnosis in each subsequent generation (anticipation). The mean age at diagnosis in the first generation was 67.8 years, 57.1 years in the second, and 41.8 years in the third (P < .0002). This was confirmed in both direct parentoffspring pairs with a mean reduction of 19 years in the age at diagnosis (P  .0087) and when the analysis was repeated only including cases of mature B-cell neoplasm (P  .0007). We believe that these families provide further insight into the nature of the underlying genetic mechanism of predisposition in these families.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Tegg, EM (Dr Elizabeth Tegg)
UTAS Author:Thomson, RJ (Dr Russell Thomson)
UTAS Author:Stankovich, JM (Dr Jim Stankovich)
UTAS Author:Banks, A (Mrs Annette Banks)
UTAS Author:Marsden, KA (Dr Katherine Marsden)
UTAS Author:Lowenthal, RM (Professor Ray Lowenthal)
UTAS Author:Foote, SJ (Professor Simon Foote)
UTAS Author:Dickinson, JL (Professor Joanne Dickinson)
ID Code:71238
Year Published:2011
Web of Science® Times Cited:9
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-07-12
Last Modified:2012-03-20

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