eCite Digital Repository

Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition

Citation

Van der Walt, A and Stankovich, J and Bahlo, M and Taylor, BV and Van der Mei, IAF and Foote, SJ and Rubio, JP and Kilpatrick, TJ and Butzkueven, H, Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition , Multiple Sclerosis, 17, (3) pp. 344-352. ISSN 1352-4585 (2011) [Refereed Article]


Preview
PDF
Restricted - Request a copy
112Kb
  

Copyright Statement

Copyright 2010 SAGE

DOI: doi:10.1177/1352458510389101

Abstract

Background: HLA-DRB1*1501 (DR15) and other HLA class II alleles increase the risk of developing multiple sclerosis (MS). However, the contribution of genetic heterogeneity to the clinical course of MS remains controversial. We examined the influence of DR15 and other common DRB1 alleles (DRB1*01 (DR1), DRB1*03 (DR3) and DRB1*04 (DR4) on MS severity in a large, Australian, population-based cohort. Methods: We studied the association between common HLA-DRB1 alleles and genotypes and age of onset as well as three clinical disease severity descriptors: Multiple Sclerosis Severity Score, progression index), and the interval between the first and second attack in 978 patients with relapsing remitting MS and secondary progressive MS. We assessed cognition using the Symbol Digit Modalities Test in 811 patients and brain atrophy using the linear magnetic resonance imaging marker, the intercaudate ratio, in 745 patients. Results: Carrying DR15 significantly decreased the age of MS onset by 3.2 years in homozygotes and 1.3 years in heterozygotes. Carrying the HLA-DR15, -DR1, -DR3 or -DR4 alone or in combination did not affect clinical disease severity, cognition or cerebral atrophy. Conclusions: This study confirms that heterogeneity of HLA-DRB1 does not influence disease outcome in relapsing MS patients, with the exception of a younger age of onset in HLA-DR15 carriers.

Item Details

Item Type:Refereed Article
Keywords:brain atrophy, cognition, HLA-DRB1, HLA-DRB1*1501, multiple sclerosis, severity
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Stankovich, J (Dr Jim Stankovich)
Author:Taylor, BV (Professor Bruce Taylor)
Author:Van der Mei, IAF (Associate Professor Ingrid van der Mei)
Author:Foote, SJ (Professor Simon Foote)
ID Code:71086
Year Published:2011
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-07-07
Last Modified:2012-06-21
Downloads:0

Repository Staff Only: item control page