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Central Hemodynamics and Cardiovascular Risk in Nondippers


Coleman, CT and Stowasser, M and Jenkins, C and Marwick, TH and Sharman, JE, Central Hemodynamics and Cardiovascular Risk in Nondippers, Journal of Clinical Hypertension , 13, (8) pp. 557-562. ISSN 1524-6175 (2011) [Refereed Article]

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Copyright 2011 Wiley Periodicals, Inc.

DOI: doi:10.1111/j.1751-7176.2011.00480.x


Failure of blood pressure (BP) to decline appropriately overnight (nondipping) is associated with increased risk. This may be due to inappropriately raised supine central BP and this study’s first aim was to examine this hypothesis. Secondly, aortic stiffness, central hemodynamics, and left ventricular (LV) mass were measured as other possible mechanisms of higher risk. Brachial and central BP (supine and seated), aortic stiffness, central hemodynamics, and LV dimensions were measured in 95 patients with hypertension (mean age 628 standard deviation). Central hemodynamics were recorded by combined radial tonometry and 3-dimensional echocardiography. Seated brachial and central systolic BP (SBP) were similar between dippers (n=52) and nondippers (n=43). However, nondippers had higher supine brachial (13214 mm Hg vs 12611 mm Hg; P=.029) and central (12115 mm Hg vs 11511 mm Hg; P=.024) SBP. Aortic stiffness was not different between groups (P=.76), but LV mass index (33.06.2 vs 29.47.2 g ⁄m2.7; P=.019), stroke volume index (30.26.2 mL⁄m2 vs 27.46.0 mL⁄m2; P=.040), and LV stroke work (3246815 mm Hg ⁄mL⁄m2 vs 2778615 mm Hg⁄mL⁄m2; P=.005) were all higher in nondippers. Dipper status independently predicted LV mass index (b=3.61; P=.001). Nondippers have higher supine brachial and central SBP, significantly different central hemodynamics, and elevated LV mass index compared with dippers. These cardiovascular anomalies possibly contribute to increased mortality risk.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Coleman, CT (Mr Cameron Coleman)
UTAS Author:Marwick, TH (Professor Tom Marwick)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:70984
Year Published:2011
Web of Science® Times Cited:13
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-07-06
Last Modified:2017-11-02

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