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Arterial stiffness, central blood pressure and body size in health and disease


Kolade, OO and O'Moore-Sullivan, TM and Stowasser, M and Coombes, JS and Fassett, RG and Marwick, TH and Sharman, JE, Arterial stiffness, central blood pressure and body size in health and disease, International Journal of Obesity, 36, (1) pp. 93-99. ISSN 0307-0565 (2011) [Refereed Article]

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Copyright 2011 Nature Publishing Group

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DOI: doi:10.1038/ijo.2011.79


Background:Body size is associated with increased brachial systolic blood pressure (SBP) and aortic stiffness. The aims of this study were to determine the relationships between central SBP and body size (determined by body mass index (BMI), waist circumference and waist/hip ratio) in health and disease. We also sought to determine if aortic stiffness was correlated with body size, independent of BP.Methods:BMI, brachial BP and estimated central SBP (by SphygmoCor and radial P2) were recorded in controls (n=228), patients with diabetes (n=211), coronary artery disease (n=184) and end-stage kidney disease (n=68). Additional measures of waist circumference and arterial stiffness (aortic and brachial pulse wave velocity (PWV)) were recorded in a subgroup of 75 controls (aged 5112 years) who were carefully screened for factors affecting vascular function.Results.BMI was associated with brachial (r=0.30; P<0.001) and central SBP (r=0.29; P<0.001) in the 228 controls, but not the patient populations (r<0.13; P>0.15 for all comparisons). In the control subgroup, waist circumference was also significantly correlated with brachial SBP (r=0.29; P=0.01), but not central SBP (r=0.22; P=0.07). Independent predictors of aortic PWV in the control subgroup were brachial SBP (=0.43; P<0.001), age (=0.37; P<0.001), waist circumference (=0.39; P=0.02) and female sex (=-0.24; P=0.03), but not BMI.Conclusion.In health, there are parallel increases in central and brachial SBP as BMI increases, but these relationships are not observed in the presence of chronic disease. Moreover, BP is a stronger correlate of arterial stiffness than body size.

Item Details

Item Type:Refereed Article
Keywords:fat, body mass index, large artery stiffness, pulse wave analysis
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Marwick, TH (Professor Tom Marwick)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:70973
Year Published:2011
Web of Science® Times Cited:28
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-07-05
Last Modified:2017-04-26

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