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P53 tumour suppressor gene expression in hyperparathyroidism


Subramaniam, P and Wilkinson, SJ and Shepherd, JJ, P53 tumour suppressor gene expression in hyperparathyroidism, Australian and New Zealand Journal of Surgery , 66, (5) pp. 302-304. ISSN 0004-8682 (1996) [Refereed Article]

DOI: doi:10.1111/j.1445-2197.1996.tb01191.x


Background: Mutations of the p53 tumour-suppressor gene lead to the loss of control of normal cellular proliferation and differentiation and have been shown to be associated with the development of malignancy. Method: Archival paraffin resection specimens from 86 cases of hyperparathyroidism treated surgically using the rabbit polyclonal CM1 antibody were investigated to detect p53 immunoreactivity in these sections. Results: Eighteen of the 86 sections examined (21%) showed nuclear immunoreactivity. No correlation was detected between tumour histology and p53 immunoreactivity (P = 0.45), nor was there any correlation between tumour clonality and immunoreactivity (P = 0.54). Multiple endocrine neoplasia type 1 (MEN 1) status did not correlate with p53; immunoreactivity. A significant correlation between p53 immunoreactivity and preparathyroidectomy calcium levels of > 1.5 mmol/L was detected (P < 0.005) although no correlation was noted between p53 immunoreactivity,and higher levels of preparathyroidectomy intact parathyroid hormone (PTH) levels. Conclusion: A relationship is postulated between abnormal serum calcium regulation and p53 mutation in hypercalcaemic states associated with hyperparathyroidism.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biotechnology
Research Field:Medical biotechnology not elsewhere classified
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Subramaniam, P ( Subramaniam)
UTAS Author:Wilkinson, SJ (Dr Stephen Wilkinson)
UTAS Author:Shepherd, JJ (Professor Joseph Shepherd)
ID Code:7095
Year Published:1996
Web of Science® Times Cited:8
Deposited By:Surgery
Deposited On:1996-08-01
Last Modified:2011-08-25

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