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Arterial stiffness: measurement and significance in management of hypertension

Citation

Sharman, JE and Marwick, TH, Arterial stiffness: measurement and significance in management of hypertension, Indian Heart Journal, 62 pp. 378-383. ISSN 0019-4832 (2010) [Refereed Article]

Abstract

Hypertension is accompanied by generalized adverse vascular functional and structural changes including increased large central artery stiffness. Aortic pulse wave velocity (PWV) is a measure of regional large artery stiffness regarded as the gold standard by expert consensus. Elevated aortic PWV imposes additional left ventricular (LV) workload through increased impedance to flow, and independently correlates with LV systolic and diastolic function, as well as cardiovascular mortality. Traditional antihypertensive drugs do not specifically target wall stiffness of the central arteries, but nonetheless may achieve a decline in aortic PWV by reducing mean arterial pressure and unloading the vessel wall. Beyond medication, regular aerobic exercise combined with sodium restricted diet (such as that advocated by the Dietary Approach to Stop Hypertension [DASH] diet) is probably the most effective way to counteract increased large central artery stiffness. This paper reviews the assessment and clinical implications of arterial stiffness in managing patients with hypertension.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Sharman, JE (Professor James Sharman)
ID Code:70893
Year Published:2010
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-07-05
Last Modified:2011-07-28
Downloads:0

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