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Complex selection associated with Hox genes in a natural population of lizards


Schwartz, TS and Perrin, C and Wapstra, E and Uller, M and Olsson, M, Complex selection associated with Hox genes in a natural population of lizards, Journal of Evolutionary Biology, 24, (11) pp. 2520-2524. ISSN 1010-061X (2011) [Refereed Article]

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DOI: doi:10.1111/j.1420-9101.2011.02368.x


Hox genes are recognized for their explanatory power of bilateral development. However, relatively little is known about natural variation in, and the evolutionary dynamics of, Hox genes within wild populations. Utilizing a natural population of sand lizards (Lacerta agilis), we screened HoxA13 for genetic variation and an association with incidence of offspring malformations. We found significant effects of parental genetic similarity and offspring sex, and their interaction, on risk of hatching malformed as an offspring. We also found within population genetic variation in HoxA13, and identified a significant effect of a three-way interaction among Hox genotype, parental genetic similarity, and offspring sex on the risk of hatching malformation. Since malformed offspring in this population do not survive to maturity, this study reveals complex and ongoing selection associated with Hox genes in a wild reptile population. Importantly, this demonstrates the utility of natural populations in unveiling microevolutionary processes shaping variation in highly conserved genes.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetics not elsewhere classified
Objective Division:Environmental Management
Objective Group:Management of Antarctic and Southern Ocean environments
Objective Field:Assessment and management of Antarctic and Southern Ocean ecosystems
UTAS Author:Wapstra, E (Associate Professor Erik Wapstra)
ID Code:70808
Year Published:2011
Web of Science® Times Cited:1
Deposited By:Zoology
Deposited On:2011-07-04
Last Modified:2018-03-17

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