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Complex selection associated with Hox genes in a natural population of lizards

Citation

Schwartz, TS and Perrin, C and Wapstra, E and Uller, M and Olsson, M, Complex selection associated with Hox genes in a natural population of lizards, Journal of Evolutionary Biology, 24, (11) pp. 2520-2524. ISSN 1010-061X (2011) [Refereed Article]


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The definitive published version is available online at: http://www3.interscience.wiley.com/

DOI: doi:10.1111/j.1420-9101.2011.02368.x

Abstract

Hox genes are recognized for their explanatory power of bilateral development. However, relatively little is known about natural variation in, and the evolutionary dynamics of, Hox genes within wild populations. Utilizing a natural population of sand lizards (Lacerta agilis), we screened HoxA13 for genetic variation and an association with incidence of offspring malformations. We found significant effects of parental genetic similarity and offspring sex, and their interaction, on risk of hatching malformed as an offspring. We also found within population genetic variation in HoxA13, and identified a significant effect of a three-way interaction among Hox genotype, parental genetic similarity, and offspring sex on the risk of hatching malformation. Since malformed offspring in this population do not survive to maturity, this study reveals complex and ongoing selection associated with Hox genes in a wild reptile population. Importantly, this demonstrates the utility of natural populations in unveiling microevolutionary processes shaping variation in highly conserved genes.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Population, Ecological and Evolutionary Genetics
Objective Division:Environment
Objective Group:Ecosystem Assessment and Management
Objective Field:Ecosystem Assessment and Management at Regional or Larger Scales
Author:Wapstra, E (Associate Professor Erik Wapstra)
ID Code:70808
Year Published:2011
Deposited By:Zoology
Deposited On:2011-07-04
Last Modified:2012-04-12
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