Dwyer, T and Ponsonby, AL and Ukoumunne, OC and Pezic, A and Venn, A and Dunstan, D and Barr, E and Blair, S and Cochrane, J and Zimmet, P and Shaw, J, Association of change in daily step count over five years with insulin sensitivity and adiposity: population based cohort study, BMJ (Online), 342 Article c7249. ISSN 1756-1833 (2011) [Refereed Article]
Copyright © T Dwyer 2011. Produced by BMJ Publishing Group Ltd under licence
Official URL: http://resources.bmj.com/bmj/authors/editorial-pol...
Objectives: To investigate the association between change in daily step count and both adiposity and insulin sensitivity and the extent to which the association between change in daily step count and insulin sensitivity may be mediated by adiposity.
Design: Population based cohort study.
Setting: Tasmania, Australia.
Participants: 592 adults (men (n=267), mean age 51.4 (SD 12.2) years; women (n=325), mean age 50.3 (12.3) years) who participated in the Tasmanian component of the national AusDiab Study in 2000 and 2005.
Main outcome measures: Body mass index, waist to hip ratio, and HOMA insulin sensitivity at follow-up in 2005. Results Over the five year period, the daily step count decreased for 65% (n=382) of participants. Having a higher daily step count in 2005 than in 2000 was independently associated with lower body mass index (0.08 (95% confidence interval 0.04 to 0.12) lower per 1000 steps), lower waist to hip ratio (0.15 (0.07 to 0.23) lower), and greater insulin sensitivity (1.38 (0.14 to 2.63) HOMA units higher) in 2005. The mean increase in HOMA units fell to 0.34 (−0.79 to 1.47) after adjustment for body mass index in 2005.
Conclusions: Among community dwelling, middle aged adults, a higher daily step count at five year follow-up than at baseline was associated with better insulin sensitivity. This effect seems to be largely mediated through lower adiposity.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Dwyer, T (Professor Terry Dwyer)|
|Author:||Ponsonby, AL (Professor Anne Ponsonby)|
|Author:||Venn, A (Professor Alison Venn)|
|Author:||Cochrane, J (Mrs Jennifer Cochrane)|
|Web of Science® Times Cited:||30|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||521 View Download Statistics|
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