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Epigenetic regulation of prostate cancer
Citation
Chin, SP and Dickinson, JL and Holloway, AF, Epigenetic regulation of prostate cancer, Clinical Epigenetics, 2, (2) pp. 151-169. ISSN 1868-7075 (2011) [Refereed Article]
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The final publication is available at http://www.springerlink.com
Official URL: http://www.springerlink.com
DOI: doi:10.1007/s13148-011-0041-7
Abstract
Prostate cancer is a commonly diagnosed cancer
in men and a leading cause of cancer deaths. Whilst the
underlying mechanisms leading to prostate cancer are still
to be determined, it is evident that both genetic and
epigenetic changes contribute to the development and
progression of this disease. Epigenetic changes involving
DNA hypo- and hypermethylation, altered histone modifications
and more recently changes in microRNA expression
have been detected at a range of genes associated with
prostate cancer. Furthermore, there is evidence that particular
epigenetic changes are associated with different stages of the
disease. Whilst early detection can lead to effective treatment,
and androgen deprivation therapy has a high response rate,
many tumours develop towards hormone-refractory prostate
cancer, for which there is no successful treatment. Reliable
markers for early detection and more effective treatment
strategies are, therefore, needed. Consequently, there is a
considerable interest in the potential of epigenetic changes as
markers or targets for therapy in prostate cancer. Epigenetic
modifiers that demethylate DNA and inhibit histone deacetylases
have recently been explored to reactivate silenced gene
expression in cancer. However, further understanding of the
mechanisms and the effects of chromatin modulation in
prostate cancer are required. In this review, we examine the
current literature on epigenetic changes associated with
prostate cancer and discuss the potential use of epigenetic
modifiers for treatment of this disease.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Prostate cancer, Epigenetics, DNA methylation, Histone acetylation, MicroRNA |
| Research Division: | Biological Sciences |
| Research Group: | Genetics |
| Research Field: | Epigenetics (incl. genome methylation and epigenomics) |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Chin, SP (Miss Paulynn Chin) |
| UTAS Author: | Dickinson, JL (Professor Joanne Dickinson) |
| UTAS Author: | Holloway, AF (Associate Professor Adele Holloway) |
| ID Code: | 70467 |
| Year Published: | 2011 |
| Web of Science® Times Cited: | 20 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2011-06-22 |
| Last Modified: | 2017-11-02 |
| Downloads: | 729 View Download Statistics |
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