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Epigenetic regulation of prostate cancer

Citation

Chin, SP and Dickinson, JL and Holloway, AF, Epigenetic regulation of prostate cancer, Clinical Epigenetics, 2, (2) pp. 151-169. ISSN 1868-7075 (2011) [Refereed Article]


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The final publication is available at http://www.springerlink.com

Official URL: http://www.springerlink.com

DOI: doi:10.1007/s13148-011-0041-7

Abstract

Prostate cancer is a commonly diagnosed cancer in men and a leading cause of cancer deaths. Whilst the underlying mechanisms leading to prostate cancer are still to be determined, it is evident that both genetic and epigenetic changes contribute to the development and progression of this disease. Epigenetic changes involving DNA hypo- and hypermethylation, altered histone modifications and more recently changes in microRNA expression have been detected at a range of genes associated with prostate cancer. Furthermore, there is evidence that particular epigenetic changes are associated with different stages of the disease. Whilst early detection can lead to effective treatment, and androgen deprivation therapy has a high response rate, many tumours develop towards hormone-refractory prostate cancer, for which there is no successful treatment. Reliable markers for early detection and more effective treatment strategies are, therefore, needed. Consequently, there is a considerable interest in the potential of epigenetic changes as markers or targets for therapy in prostate cancer. Epigenetic modifiers that demethylate DNA and inhibit histone deacetylases have recently been explored to reactivate silenced gene expression in cancer. However, further understanding of the mechanisms and the effects of chromatin modulation in prostate cancer are required. In this review, we examine the current literature on epigenetic changes associated with prostate cancer and discuss the potential use of epigenetic modifiers for treatment of this disease.

Item Details

Item Type:Refereed Article
Keywords:Prostate cancer, Epigenetics, DNA methylation, Histone acetylation, MicroRNA
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Epigenetics (incl. Genome Methylation and Epigenomics)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Chin, SP (Miss Paulynn Chin)
Author:Dickinson, JL (Associate Professor Joanne Dickinson)
Author:Holloway, AF (Dr Adele Holloway)
ID Code:70467
Year Published:2011
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-06-22
Last Modified:2017-11-02
Downloads:582 View Download Statistics

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