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Impact of depression treatment on mental and physical health-related quality of life of cardiac patients: A meta-analysis

journal contribution
posted on 2023-05-17, 06:27 authored by O'Neil, A, Kristy Sanderson, Oldenberg, B, Taylor, CB
PURPOSE: To conduct a meta-analysis evaluating the effectiveness of depression treatment on mental and physical health-related quality of life (HRQOL) of cardiac patients. METHODS: Studies were identified using medical, health, psychiatry, psychology, and social sciences databases. Inclusion criteria were (1) 1 or more control conditions, (2) random assignment to condition after admission for myocardial infarction (MI)(acute coronary syndrome, after recording positive results on a depression screener, (3) documentation of depression symptoms at baseline, (4) depression management as a component of the rehabilitation/intervention, (5) validated measure of HRQOL as an outcome, at minimum 6-month followup. For meta-analysis, mental and physical HRQOL were the end points studied, using standardized mean differences for continuous outcome measures, with 95% confidence intervals. Heterogeneity was explored by calculating I2 statistic. RESULTS: Five randomized controlled trials included in the analysis represented 2105 participants (1058 intervention vs 1047 comparator). Compared with a comparator group at 6 months, a test for overall effect demonstrated statistically significant improvements in mental HRQOL in favor of the intervention (standardized mean differences = -0.29 [-0.38 to -0.20], [P < .00001]; B= 0%). Depression treatment had a modest yet significant impact on physical HRQOL ( standardized mean differences = -0.14 [-0.24 to -0.04] [P - .009]; B= 15%). CONCLUSION: While the impact of post-MI depression interventions on physical HRQOL is modest, treatment can improve mental HRQOL in a significant way. Future research is required to develop and evaluate a program that can achieve vital improvements in overall HRQOL, and potentially cardiovascular outcomes, of cardiac patients.

History

Publication title

Journal of Cardiopulmonary Rehabilitation and Prevention

Volume

31

Pagination

146-156

ISSN

1932-7501

Department/School

Menzies Institute for Medical Research

Publisher

Lippincott Williams & Wilkins

Place of publication

United States

Rights statement

Copyright © 2011 Lippincott Williams & Wilkins

Repository Status

  • Restricted

Socio-economic Objectives

Mental health

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