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Impact of depression treatment on mental and physical health-related quality of life of cardiac patients: A meta-analysis


O'Neil, A and Sanderson, K and Oldenberg, B and Taylor, CB, Impact of depression treatment on mental and physical health-related quality of life of cardiac patients: A meta-analysis, Journal of Cardiopulmonary Rehabilitation and Prevention , 31, (3) pp. 146-156. ISSN 1932-7501 (2011) [Refereed Article]

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Copyright Statement

Copyright 2011 Lippincott Williams & Wilkins

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DOI: doi:10.1097/HCR.0b013e3181fc0985


PURPOSE: To conduct a meta-analysis evaluating the effectiveness of depression treatment on mental and physical health-related quality of life (HRQOL) of cardiac patients. METHODS: Studies were identified using medical, health, psychiatry, psychology, and social sciences databases. Inclusion criteria were (1) 1 or more control conditions, (2) random assignment to condition after admission for myocardial infarction (MI)(acute coronary syndrome, after recording positive results on a depression screener, (3) documentation of depression symptoms at baseline, (4) depression management as a component of the rehabilitation/intervention, (5) validated measure of HRQOL as an outcome, at minimum 6-month followup. For meta-analysis, mental and physical HRQOL were the end points studied, using standardized mean differences for continuous outcome measures, with 95% confidence intervals. Heterogeneity was explored by calculating I2 statistic. RESULTS: Five randomized controlled trials included in the analysis represented 2105 participants (1058 intervention vs 1047 comparator). Compared with a comparator group at 6 months, a test for overall effect demonstrated statistically significant improvements in mental HRQOL in favor of the intervention (standardized mean differences  0.29 [0.38 to 0.20], [P  .00001]; I2 0%). Depression treatment had a modest yet significant impact on physical HRQOL ( standardized mean differences  0.14 [0.24 to 0.04] [P  .009]; I2 15%). CONCLUSION: While the impact of post-MI depression interventions on physical HRQOL is modest, treatment can improve mental HRQOL in a significant way. Future research is required to develop and evaluate a program that can achieve vital improvements in overall HRQOL, and potentially cardiovascular outcomes, of cardiac patients.

Item Details

Item Type:Refereed Article
Keywords:depression treatment, health-related quality of life, mental health functioning, myocardial infarction, physical health functioning
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Sanderson, K (Associate Professor Kristy Sanderson)
ID Code:70448
Year Published:2011
Web of Science® Times Cited:20
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-06-21
Last Modified:2012-03-19
Downloads:2 View Download Statistics

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