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NG2-glia as multipotent neural stem cells: Fact or fantasy?

Citation

Richardson, WD and Young, KM and Tripathi, RB and McKenzie, I, NG2-glia as multipotent neural stem cells: Fact or fantasy?, Neuron, 70, (4) pp. 661-673. ISSN 0896-6273 (2011) [Refereed Article]


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DOI: doi:10.1016/j.neuron.2011.05.013

Abstract

Cycling glial precursors—‘‘NG2-glia’’—are abundant in the developing and mature central nervous system (CNS). During development, they generate oligodendrocytes. In culture, they can revert to a multipotent state, suggesting that they might have latent stem cell potential that could be harnessed to treat neurodegenerative disease. This hope has been subdued recently by a series of fate-mapping studies that cast NG2-glia as dedicated oligodendrocyte precursors in the healthy adult CNS—though rare, neuron production in the piriform cortex remains a possibility. Following CNS damage, the repertoire of NG2-glia expands to include Schwann cells and possibly astrocytes—but so far not neurons. This reaffirms the central role of NG2-glia in myelin repair. The realization that oligodendrocyte generation continues throughout normal adulthood has seeded the idea that myelin genesis might also be involved in neural plasticity. We review these developments, highlighting areas of current interest, contention, and speculation.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Young, KM (Dr Kaylene Young)
ID Code:70237
Year Published:2011
Web of Science® Times Cited:140
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-06-10
Last Modified:2012-03-19
Downloads:0

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