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Characterisation of G8 human rotaviruses in Australian children with gastroenteritis


Swiatek, DL and Palombo, EA and Lee, A and Coventry, MJ and Britz, ML and Kirkwood, CD, Characterisation of G8 human rotaviruses in Australian children with gastroenteritis, Virus Research: An International Journal of Molecular and Cellular Virology, 148, (1-2) pp. 1-7. ISSN 0168-1702 (2010) [Refereed Article]

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DOI: doi:10.1016/j.virusres.2009.11.013


Abstract: This study describes the characterisation of G8 rotavirus strains isolated from humans with acute gastroenteritis. Six G8 strains were detected in Australia between 2002 and 2008. Four were G8P[14] strains, one was G8P[8]+ [14] and one was G8 P non-typeable. By polyacrylamide gel electrophoresis and enzyme immurroassay analysis, four G8 strains with visible RNA exhibited a long electropherotype and five G8 strains displayed subgroup I specificity. Sequence analysis of the VP7 gene indicated that the G8 strains exhibited the highest nucleotide and amino acid identity with a G8P[11] bovine rotavirus strain detected in Japan. VP4 sequence data ofone G8P[14] strain revealed that the closest identity was to another human-bovine-like strain detected in Australia, MG6, a G6P[14] strain. The identification of G8 strains causing disease further extends the number of G8P[14] strains detected in Australian children, and indicates that there is a Fare but ongoing presence of uncommon human strains within the community in Australia. (c) 2009 Elsevier B.V. All rights reserved.

Item Details

Item Type:Refereed Article
Keywords:Human rotavirus; Interspecies transmission; VP7; VP4
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Food sciences
Research Field:Food sciences not elsewhere classified
Objective Division:Manufacturing
Objective Group:Dairy products
Objective Field:Dairy products not elsewhere classified
UTAS Author:Britz, ML (Professor Margaret Britz)
ID Code:70182
Year Published:2010
Web of Science® Times Cited:16
Deposited By:Agricultural Science
Deposited On:2011-06-07
Last Modified:2015-02-05

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