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Target populations for first-in-human embryonic stem cell research in spinal cord injury

journal contribution
posted on 2023-05-17, 06:16 authored by Bretzner, F, Frederic GilbertFrederic Gilbert, Baylis, F, Brownstone, R
Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs).This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, subacute incomplete SCI patients for an efficacy trial, and perhaps primary progressive multiple sclerosis (MS) patients for a combined safety and efficacy trial.

History

Publication title

Cell Stem Cell

Volume

8

Issue

5

Pagination

468-475

ISSN

1934-5909

Department/School

School of Humanities

Publisher

Elsevier

Place of publication

Cambridge MA

Rights statement

The definitive version is available at http://www.sciencedirect.com

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in philosophy and religious studies

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