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Target populations for first-in-human embryonic stem cell research in spinal cord injury
Citation
Bretzner, F and Gilbert, F and Baylis, F and Brownstone, R, Target populations for first-in-human embryonic stem cell research in spinal cord injury, Cell Stem Cell, 8, (5) pp. 468-475. ISSN 1934-5909 (2011) [Refereed Article]
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DOI: doi:10.1016/j.stem.2011.04.012
Abstract
Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs).This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, subacute incomplete SCI patients for an efficacy trial, and perhaps primary progressive multiple sclerosis (MS) patients for a combined safety and efficacy trial.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | embryonic stem cell research, spinal cord injury, phase 1 clinical trial |
| Research Division: | Philosophy and Religious Studies |
| Research Group: | Applied ethics |
| Research Field: | Ethical use of new technology |
| Objective Division: | Expanding Knowledge |
| Objective Group: | Expanding knowledge |
| Objective Field: | Expanding knowledge in philosophy and religious studies |
| UTAS Author: | Gilbert, F (Dr Frederic Gilbert) |
| ID Code: | 69992 |
| Year Published: | 2011 |
| Web of Science® Times Cited: | 83 |
| Deposited By: | Philosophy |
| Deposited On: | 2011-05-26 |
| Last Modified: | 2018-01-25 |
| Downloads: | 2 View Download Statistics |
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