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Target populations for first-in-human embryonic stem cell research in spinal cord injury


Bretzner, F and Gilbert, F and Baylis, F and Brownstone, R, Target populations for first-in-human embryonic stem cell research in spinal cord injury, Cell Stem Cell, 8, (5) pp. 468-475. ISSN 1934-5909 (2011) [Refereed Article]

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DOI: doi:10.1016/j.stem.2011.04.012


Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs).This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, subacute incomplete SCI patients for an efficacy trial, and perhaps primary progressive multiple sclerosis (MS) patients for a combined safety and efficacy trial.

Item Details

Item Type:Refereed Article
Keywords:embryonic stem cell research, spinal cord injury, phase 1 clinical trial
Research Division:Philosophy and Religious Studies
Research Group:Applied ethics
Research Field:Ethical use of new technology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in philosophy and religious studies
UTAS Author:Gilbert, F (Associate Professor Frederic Gilbert)
ID Code:69992
Year Published:2011
Web of Science® Times Cited:85
Deposited By:Philosophy
Deposited On:2011-05-26
Last Modified:2018-01-25
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