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Hardwiring the bain: Endocannabinoids shape neuronal connectivity
journal contribution
posted on 2023-05-17, 06:15 authored by Berghuis, P, Rajnicek, AM, Morozov, YM, Ross, RA, Mulder, J, Urban, GM, Monory, K, Marsicano, G, Matteoli, M, Alison CantyAlison Canty, Irving, AJ, Katona, I, Yanagawa, Y, Rakic, P, Lutz, B, Mackie, K, Harkany, TThe roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB(1) cannabinoid receptors (CB(1)Rs) are enriched in the axonal growth cones of gamma-aminobutyric acid-containing (GABAergic) interneurons in the rodent cortex during late gestation. Endocannabinoids trigger CB(1)R internalization and elimination from filopodia and induce chemorepulsion and collapse of axonal growth cones of these GABAergic interneurons by activating RhoA. Similarly, endocannabinoids diminish the galvanotropism of Xenopus laevis spinal neurons. These findings, together with the impaired target selection of cortical GABAergic interneurons lacking CB(1)Rs, identify endocannabinoids as axon guidance cues and demonstrate that endocannabinoid signaling regulates synaptogenesis and target selection in vivo.
History
Publication title
ScienceVolume
316Issue
5828Pagination
1212-1216ISSN
0036-8075Department/School
Tasmanian School of MedicinePublisher
Amer Assoc Advancement SciencePlace of publication
1200 New York Ave, Nw, Washington, USA, Dc, 20005Repository Status
- Restricted