eCite Digital Repository

Hardwiring the bain: Endocannabinoids shape neuronal connectivity


Berghuis, P and Rajnicek, AM and Morozov, YM and Ross, RA and Mulder, J and Urban, GM and Monory, K and Marsicano, G and Matteoli, M and Canty, A and Irving, AJ and Katona, I and Yanagawa, Y and Rakic, P and Lutz, B and Mackie, K and Harkany, T, Hardwiring the bain: Endocannabinoids shape neuronal connectivity, Science, 316, (5828) pp. 1212-1216. ISSN 0036-8075 (2007) [Refereed Article]

DOI: doi:10.1126/science.1137406


The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB(1) cannabinoid receptors (CB(1)Rs) are enriched in the axonal growth cones of gamma-aminobutyric acid-containing (GABAergic) interneurons in the rodent cortex during late gestation. Endocannabinoids trigger CB(1)R internalization and elimination from filopodia and induce chemorepulsion and collapse of axonal growth cones of these GABAergic interneurons by activating RhoA. Similarly, endocannabinoids diminish the galvanotropism of Xenopus laevis spinal neurons. These findings, together with the impaired target selection of cortical GABAergic interneurons lacking CB(1)Rs, identify endocannabinoids as axon guidance cues and demonstrate that endocannabinoid signaling regulates synaptogenesis and target selection in vivo.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Canty, A (Associate Professor Alison Canty)
ID Code:69930
Year Published:2007
Web of Science® Times Cited:374
Deposited By:Medicine
Deposited On:2011-05-25
Last Modified:2012-04-20

Repository Staff Only: item control page