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The DIADEM Data Sets: Representative Light Microscopy Images of Neuronal Morphology to Advance Automation of Digital Reconstructions
journal contribution
posted on 2023-05-17, 06:14 authored by Brown, KM, Barrionuevo, G, Alison CantyAlison Canty, De Paola, V, Hirsch, JA, Jefferis, GSXE, Lu, J, Snippe, M, Sugihara, I, Ascoli, GAThe comprehensive characterization of neuronal morphology requires tracing extensive axonal and dendritic arbors imaged with light microscopy into digital reconstructions. Considerable effort is ongoing to automate this greatly labor-intensive and currently rate-determining process. Experimental data in the form of manually traced digital reconstructions and corresponding image stacks play a vital role in developing increasingly more powerful reconstruction algorithms. The DIADEM challenge (short for DIgital reconstruction of Axonal and DEndritic Morphology) successfully stimulated progress in this area by utilizing six data set collections from different animal species, brain regions, neuron types, and visualization methods. The original research projects that provided these data are representative of the diverse scientific questions addressed in this field. At the same time, these data provide a benchmark for the types of demands automated software must meet to achieve the quality of manual reconstructions while minimizing human involvement. The DIADEM data underwent extensive curation, including quality control, metadata annotation, and format standardization, to focus the challenge on the most substantial technical obstacles. This data set package is now freely released ( http://diademchallenge.org ) to train, test, and aid development of automated reconstruction algorithms
History
Publication title
NeuroinformaticsVolume
9Issue
2-3Pagination
143-157ISSN
1539-2791Department/School
Tasmanian School of MedicinePublisher
Humana Press IncPlace of publication
999 Riverview Drive Suite 208, Totowa, USA, Nj, 07512Rights statement
Copyright 2011 Springer Science+Business Media.Repository Status
- Restricted