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Lifestyle Change Diminishes a Hypertensive Response to Exercise in Type 2 Diabetes
Citation
Schultz, MG and Hordern, MD and Leano, R and Coombes, JS and Marwick, TH and Sharman, JE, Lifestyle Change Diminishes a Hypertensive Response to Exercise in Type 2 Diabetes, Medicine and Science in Sports and Exercise, 43, (5) pp. 764-769. ISSN 0195-9131 (2011) [Refereed Article]
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Copyright Statement
Copyright © 2011 Lippincott Williams & Wilkins
Official URL: http://www.lww.com/
DOI: doi:10.1249/MSS.0b013e3181fcf034
Abstract
Purpose: A hypertensive response to exercise (HRE) is common in patients with type 2 diabetes and is associated with increased left
ventricular (LV) mass and mortality. This study aimed to determine whether lifestyle modification would improve exercise blood
pressure (BP) and reduce LV mass in patients with type 2 diabetes. Methods: One hundred and eighty-five patients with type 2
diabetes were randomized to 1 yr of lifestyle intervention (n = 97, mean T SD age = 54.7 T 11.3 yr, 51% men) or usual care (control;
n = 88, age = 53.8 T 8.1 yr, 61% men). Brachial BP was measured at rest and during a graded maximal exercise test at baseline and
1 yr. Patients also underwent two-dimensional echocardiography to determine LV dimensions. A subgroup of 61 patients had resting
and exercise central BP estimated from radial tonometry. An HRE was defined as a maximal exercise systolic BP of Q210 mm Hg for
men and Q190 mm Hg for women. Results: At study entry, there were 101 patients (55%) with an HRE (n = 51 controls). Compared
with controls, lifestyle intervention significantly reduced the propensity to develop an HRE in those participants who did not have
HRE at baseline (29.8% vs 59.5%, P = 0.006). However, absolute values of exercise and resting (brachial and central) BP and LV
mass were not significantly changed (all P values 9 0.05). There were significant (all P values G 0.05) improvements inV˙ O2max, body
mass index, plasma glucose, insulin resistance, and HDL cholesterol after lifestyle intervention compared with control. Conclusions:
Lifestyle intervention significantly attenuates the development of an HRE but does not reduce cardiac size after 1 yr in patients
with type 2 diabetes.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | Lifestyle modification; exercise; blood pressure; hypertension |
Research Division: | Medical and Health Sciences |
Research Group: | Cardiorespiratory Medicine and Haematology |
Research Field: | Cardiology (incl. Cardiovascular Diseases) |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Cardiovascular System and Diseases |
UTAS Author: | Schultz, MG (Dr Martin Schultz) |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
UTAS Author: | Sharman, JE (Professor James Sharman) |
ID Code: | 69754 |
Year Published: | 2011 |
Web of Science® Times Cited: | 13 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2011-05-17 |
Last Modified: | 2014-05-05 |
Downloads: | 2 View Download Statistics |
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