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Objective: To examine the effect of lifestyle changes on the stability of blood lipid and lipoprotein levels from youth to adulthood. Design: Prospective cohort study. Setting: Australia. Participants: Five hundred thirty-nine young adults who underwent measurement at baseline in 1985 when aged 9, 12, or 15 years and again at follow-up between 2004 and 2006. Main Exposures: Changes in adiposity, cardiorespiratory fitness, saturated fat intake, smoking, and socioeconomic position. Main OutcomeMeasures: Child and adult blood lipid levels. Results: Using established cut points, we found that substantial proportions of individuals with high-risk blood lipid and lipoprotein levels at baseline no longer had highrisk levels at follow-up. Of the participants who had highrisk levels in youth, those with greater increases in adiposity or who commenced or continued smoking were more likely to maintain high-risk blood lipid and lipoprotein levels (P.05). Participants who became high risk at follow-up had greater increases in adiposity, were less likely to improve their socioeconomic position, and tended to become less fit between surveys compared with those who maintained normal-risk levels (P.05). These effects tended to remain (P.10) after adjustment for all predictive lifestyle variables.

Item Type:	Refereed Article
Research Division:	Medical and Health Sciences
Research Group:	Cardiorespiratory Medicine and Haematology
Research Field:	Cardiology (incl. Cardiovascular Diseases)
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Cardiovascular System and Diseases
Author:	Magnussen, CG (Dr Costan Magnussen)
Author:	Thomson, R (Dr Russell Thomson)
Author:	Cleland, VJ (Dr Verity Cleland)
Author:	Venn, A (Professor Alison Venn)
ID Code:	69666
Year Published:	2011
Web of Science® Times Cited:	24
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2011-05-12
Last Modified:	2012-03-19
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