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Factors Affecting the Stability of Blood Lipid and Lipoprotein Levels From Youth to Adulthood: Evidence from the Childhood Determinants of Adult Health Study

Citation

Magnussen, CG and Thomson, R and Cleland, VJ and Ukoumunne, OC and Dwyer, T and Venn, A, Factors Affecting the Stability of Blood Lipid and Lipoprotein Levels From Youth to Adulthood: Evidence from the Childhood Determinants of Adult Health Study, Archives of Pediatrics and Adolescent Medicine, 165, (1) pp. 68-76. ISSN 1072-4710 (2011) [Refereed Article]


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Copyright Statement

Copyright © 2011 American Medical Association.

Official URL: http://jama.ama-assn.org/

DOI: doi:10.1001/archpediatrics.2010.246

Abstract

Objective: To examine the effect of lifestyle changes on the stability of blood lipid and lipoprotein levels from youth to adulthood. Design: Prospective cohort study. Setting: Australia. Participants: Five hundred thirty-nine young adults who underwent measurement at baseline in 1985 when aged 9, 12, or 15 years and again at follow-up between 2004 and 2006. Main Exposures: Changes in adiposity, cardiorespiratory fitness, saturated fat intake, smoking, and socioeconomic position. Main OutcomeMeasures: Child and adult blood lipid levels. Results: Using established cut points, we found that substantial proportions of individuals with high-risk blood lipid and lipoprotein levels at baseline no longer had highrisk levels at follow-up. Of the participants who had highrisk levels in youth, those with greater increases in adiposity or who commenced or continued smoking were more likely to maintain high-risk blood lipid and lipoprotein levels (P.05). Participants who became high risk at follow-up had greater increases in adiposity, were less likely to improve their socioeconomic position, and tended to become less fit between surveys compared with those who maintained normal-risk levels (P.05). These effects tended to remain (P.10) after adjustment for all predictive lifestyle variables.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Magnussen, CG (Dr Costan Magnussen)
Author:Thomson, R (Dr Russell Thomson)
Author:Cleland, VJ (Dr Verity Cleland)
Author:Venn, A (Professor Alison Venn)
ID Code:69666
Year Published:2011
Web of Science® Times Cited:23
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-05-12
Last Modified:2012-03-19
Downloads:0

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