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Factors Affecting the Stability of Blood Lipid and Lipoprotein Levels From Youth to Adulthood: Evidence from the Childhood Determinants of Adult Health Study
Citation
Magnussen, CG and Thomson, R and Cleland, VJ and Ukoumunne, OC and Dwyer, T and Venn, A, Factors Affecting the Stability of Blood Lipid and Lipoprotein Levels From Youth to Adulthood: Evidence from the Childhood Determinants of Adult Health Study, Archives of Pediatrics and Adolescent Medicine, 165, (1) pp. 68-76. ISSN 1072-4710 (2011) [Refereed Article]
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Copyright Statement
Copyright © 2011 American Medical Association.
Official URL: http://jama.ama-assn.org/
DOI: doi:10.1001/archpediatrics.2010.246
Abstract
Objective: To examine the effect of lifestyle changes on
the stability of blood lipid and lipoprotein levels from
youth to adulthood.
Design: Prospective cohort study.
Setting: Australia.
Participants: Five hundred thirty-nine young adults who
underwent measurement at baseline in 1985 when aged
9, 12, or 15 years and again at follow-up between 2004
and 2006.
Main Exposures: Changes in adiposity, cardiorespiratory
fitness, saturated fat intake, smoking, and socioeconomic
position.
Main OutcomeMeasures: Child and adult blood lipid
levels.
Results: Using established cut points, we found that substantial
proportions of individuals with high-risk blood
lipid and lipoprotein levels at baseline no longer had highrisk
levels at follow-up. Of the participants who had highrisk
levels in youth, those with greater increases in adiposity
or who commenced or continued smoking were
more likely to maintain high-risk blood lipid and lipoprotein
levels (P.05). Participants who became high
risk at follow-up had greater increases in adiposity, were
less likely to improve their socioeconomic position, and
tended to become less fit between surveys compared with
those who maintained normal-risk levels (P.05). These
effects tended to remain (P.10) after adjustment for
all predictive lifestyle variables.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Medical and Health Sciences |
| Research Group: | Cardiorespiratory Medicine and Haematology |
| Research Field: | Cardiology (incl. Cardiovascular Diseases) |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Cardiovascular System and Diseases |
| UTAS Author: | Magnussen, CG (Dr Costan Magnussen) |
| UTAS Author: | Thomson, R (Dr Russell Thomson) |
| UTAS Author: | Cleland, VJ (Associate Professor Verity Cleland) |
| UTAS Author: | Venn, A (Professor Alison Venn) |
| ID Code: | 69666 |
| Year Published: | 2011 |
| Web of Science® Times Cited: | 26 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2011-05-12 |
| Last Modified: | 2012-03-19 |
| Downloads: | 0 |
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