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Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade

Citation

du Bois, TM and Hsu, CW and Li, Y and Tan, YY and Deng, C and Huang, XF, Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade, Neurochemical Research, 33, (7) pp. 1224-1231. ISSN 0364-3190 (2008) [Refereed Article]


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The final publication is available at http://www.springerlink.com

Official URL: http://www.springerlink.com

DOI: doi:10.1007/s11064-007-9571-y

Abstract

This study examined how perinatal phencyclidine (PCP) treatment would affect dopamine D2 receptor and dopamine transporter (DAT) binding at different stages after treatment cessation. Female rat pups received injections of PCP (10 mg/kg, s.c.) or saline on postnatal day (PN)7, 9 and 11. D2 receptor and transporter binding was examined at four time-points (PN12, 18, 32 and 96) following injections. PCP treatment altered D2 receptor binding throughout development, with a final end-point of 22–33% decreased binding at adulthood in the nucleus accumbens and caudate putamen (P\0.01), accompanied by a small but significant increase in DAT binding in the caudate putamen. Tyrosine hydroxylase mRNA expression was also significantly increased by 25% (P\0.05) in the ventral tegmental area of adult rats, suggesting that this model may produce a long-term increase in dopamine output. This study demonstrates that early insult to the brain from NMDA receptor hypofunction alters the dopaminergic system at different stages of development.

Item Details

Item Type:Refereed Article
Keywords:Brain development  NMDA receptor Phencyclidine  Dopaminergic system
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Basic Pharmacology
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Tan, YY (Dr Yean Tan)
ID Code:69540
Year Published:2008
Web of Science® Times Cited:22
Deposited By:Pharmacy
Deposited On:2011-04-28
Last Modified:2011-07-28
Downloads:0

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