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Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish


Richardson, SJ and Monk, JA and Shepherdley, CA and Ebbesson, LOE and Sin, F and Power, DM and Frappell, P and Kohrle, J and Renfree, MB, Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 288, (5) pp. 1264-1272. ISSN 0363-6119 (2005) [Refereed Article]

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Copyright 2005 The American Physiological Society

DOI: doi:10.1152/ajpregu.00793.2004


Thyroid hormones are essential for vertebrate development. There is a characteristic rise in thyroid hormone levels in blood during critical periods of thyroid hormone-regulated development. Thyroid hormones are lipophilic compounds, which readily partition from an aqueous environment into a lipid environment. Thyroid hormone distributor proteins are required to ensure adequate distribution of thyroid hormones, throughout the aqueous environment of the blood, and to counteract the avid partitioning of thyroid hormones into the lipid environment of cell membranes. In human blood, these proteins are albumin, transthyretin and thyroxine-binding globulin. We analyzed the developmental profile of thyroid hormone distributor proteins in serum from a representative of each order of marsupials (M. eugenii; S.crassicaudata), a reptile (C. porosus), in two species of salmonoid fishes (S. salar; O. tshawytsch), and throughout a calendar year for sea bream (S. aurata). We demonstrated that during development, these animals have a thyroid hormone distributor protein present in their blood which is not present in the adult blood. At least in mammals, this additional protein has higher affinity for thyroid hormones than the thyroid hormone distributor proteins in the blood of the adult. In fish, reptile and polyprotodont marsupial, this protein was transthyretin. In a diprotodont marsupial, it was thyroxine-binding globulin. We propose an hypothesis that an augmented thyroid hormone distributor protein network contributes to the rise in total thyroid hormone levels in the blood during development.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Zoology
Research Field:Comparative physiology
Objective Division:Animal Production and Animal Primary Products
Objective Group:Other animal production and animal primary products
Objective Field:Animal welfare
UTAS Author:Frappell, P (Professor Peter Frappell)
ID Code:68894
Year Published:2005
Web of Science® Times Cited:38
Deposited By:Zoology
Deposited On:2011-03-30
Last Modified:2011-08-19

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