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Creatine phosphate as the preferred early indicator of ischemia in muscular tissues
Citation
Ye, JM and Clark, MG and Colquhoun, EQ, Creatine phosphate as the preferred early indicator of ischemia in muscular tissues, Journal of Surgical Research, 61, (1) pp. 227-236. ISSN 0022-4804 (1996) [Refereed Article]
DOI: doi:10.1006/jsre.1996.0109
Abstract
Changes in creatine compounds, especially the creatine phosphate to creatine ratio (CrP/Cr), are more sensitive indicators than changes in other metabolites for early ischemia in the different muscular tissues of heart, small intestine, skeletal muscle, and aorta. Changes in adenine nucleotide ratios are buffered by CrP reserves and the absolute concentration of adenine nucleotides can vary greatly between different muscular tissues. Accumulation of lactate is indicative of ischemia, but is not as sensitive as the ratio of CrP/Cr, but may better indicate the duration of ischemia. Glycerol also accumulates in muscular tissues during prolonged ischemia, so that consideration of both lactate and glycerol levels together, might confer a better estimate of the duration of ischemia of different muscular tissues.
Item Details
Item Type: | Refereed Article |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Medical biochemistry and metabolomics |
Research Field: | Medical biochemistry and metabolomics not elsewhere classified |
Objective Division: | Health |
Objective Group: | Other health |
Objective Field: | Other health not elsewhere classified |
UTAS Author: | Ye, JM (Associate Professor Jiming Ye) |
UTAS Author: | Clark, MG (Professor Michael Clark) |
UTAS Author: | Colquhoun, EQ (Dr Eric Colquhoun) |
ID Code: | 6861 |
Year Published: | 1996 |
Web of Science® Times Cited: | 17 |
Deposited By: | Biochemistry |
Deposited On: | 1996-08-01 |
Last Modified: | 2011-08-16 |
Downloads: | 0 |
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