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Creatine phosphate as the preferred early indicator of ischemia in muscular tissues
journal contribution
posted on 2023-05-16, 10:03 authored by Ye, JM, Michael ClarkMichael Clark, Colquhoun, EQChanges in creatine compounds, especially the creatine phosphate to creatine ratio (CrP/Cr), are more sensitive indicators than changes in other metabolites for early ischemia in the different muscular tissues of heart, small intestine, skeletal muscle, and aorta. Changes in adenine nucleotide ratios are buffered by CrP reserves and the absolute concentration of adenine nucleotides can vary greatly between different muscular tissues. Accumulation of lactate is indicative of ischemia, but is not as sensitive as the ratio of CrP/Cr, but may better indicate the duration of ischemia. Glycerol also accumulates in muscular tissues during prolonged ischemia, so that consideration of both lactate and glycerol levels together, might confer a better estimate of the duration of ischemia of different muscular tissues.
History
Publication title
Journal of Surgical ResearchVolume
61Pagination
227-236ISSN
0022-4804Department/School
Tasmanian School of MedicinePublisher
Academic Press Inc Elsevier SciencePlace of publication
USARepository Status
- Restricted