Changes in creatine compounds, especially the creatine phosphate to creatine ratio (CrP/Cr), are more sensitive indicators than changes in other metabolites for early ischemia in the different muscular tissues of heart, small intestine, skeletal muscle, and aorta. Changes in adenine nucleotide ratios are buffered by CrP reserves and the absolute concentration of adenine nucleotides can vary greatly between different muscular tissues. Accumulation of lactate is indicative of ischemia, but is not as sensitive as the ratio of CrP/Cr, but may better indicate the duration of ischemia. Glycerol also accumulates in muscular tissues during prolonged ischemia, so that consideration of both lactate and glycerol levels together, might confer a better estimate of the duration of ischemia of different muscular tissues.

Item Type:	Refereed Article
Research Division:	Medical and Health Sciences
Research Group:	Medical Biochemistry and Metabolomics
Research Field:	Medical Biochemistry and Metabolomics not elsewhere classified
Objective Division:	Health
Objective Group:	Other Health
Objective Field:	Health not elsewhere classified
Author:	Ye, JM (Associate Professor Jiming Ye)
Author:	Clark, MG (Professor Michael Clark)
Author:	Colquhoun, EQ (Dr Eric Colquhoun)
ID Code:	6861
Year Published:	1996
Web of Science® Times Cited:	17
Deposited By:	Biochemistry
Deposited On:	1996-08-01
Last Modified:	2011-08-16
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