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PPAR gamma agonists attenuate proliferation and modulate Wnt/‚-catenin signalling in melanoma cells


Smith, AG and Beaumont, KA and Smit, DJ and Thurber, AE and Cook, AL and Boyle, GM and Parsons, PG and Sturm, RA and Muscat, GEO, PPAR gamma agonists attenuate proliferation and modulate Wnt/a-catenin signalling in melanoma cells, International Journal of Biochemistry and Cell Biology, 41, (4) pp. 844-852. ISSN 1357-2725 (2008) [Refereed Article]

DOI: doi:10.1016/j.biocel.2008.08.037


Peroxisome proliferator-activated receptor-gamma (PPAR„) is a member of the nuclear hormone receptor (NHR) superfamily of ligand-activated transcriptional regulators. Accumulating evidence suggests that PPAR„ agonists such as the thiazolidinediones (TZDs) may prove to be useful anti-cancer agents exhibiting anti-proliferative and/or pro-apoptotic affects in a range of cancer cell types including melanoma, however, the mechanisms underlying this effect remain unclear. We have demonstrated the anti-proliferative effects of full and partial PPAR„ modulators in human melanoma cell lines. Ablation of PPAR„ expression in the MM96L melanoma cell line by siRNA mediated mechanisms attenuates the anti-proliferative effect of these agents suggesting this effect is directly mediated by PPAR„. The mechanisms underlying the anti-proliferative effects of PPAR„ in melanoma cells involve the regulation of expression of a number of critical cell cycle genes and ‚-catenin. Moreover, our data indicate that PPAR„ modulates Wnt/‚-catenin mediated signalling in melanoma cells in an agonist dependent manner.

Item Details

Item Type:Refereed Article
Keywords:Melanoma; PPAR; Beta-catenin; Nuclear receptor
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer genetics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Cook, AL (Associate Professor Tony Cook)
ID Code:68255
Year Published:2008
Web of Science® Times Cited:23
Deposited By:Health Sciences A
Deposited On:2011-03-10
Last Modified:2011-03-10

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