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Tumor necrosis factor negative bone marrow-derived dendritic cells exhibit deficient IL-10 expression


Roomberg, A and Kling, J and Fromm, P and Korner, H, Tumor necrosis factor negative bone marrow-derived dendritic cells exhibit deficient IL-10 expression, Immunology and Cell Biology, 88, (8) pp. 842-845. ISSN 0818-9641 (2010) [Refereed Article]

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DOI: doi:10.1038/icb.2010.54


The effective maturation of dendritic cells (DC) is complex and highly regulated and requires the presence of a variety of signals. Tumor necrosis factor (TNF) and its receptors or innate pattern recognition receptors such as the toll-like receptors have been shown to contribute to this process. DC derived from bone marrow cells in the presence of granulocyte/macrophage colony-stimulating factor can be used as a model to ascertain the contribution of different signals to DC maturation. Analysis of DC activated by addition of the mycobacterial vaccine strain Bacillus Calmette-Gue´ rin showed that of the effector molecules studied only interleukin-10 expression was significantly reduced in TNF-negative (B6.TNF/) DC. Another effector molecule produced by DC, inducible nitric oxide synthase, was largely unchanged.

Item Details

Item Type:Refereed Article
Keywords:mycobacteria; tumor necrosis factor; interleukin-10; dendritic cells
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Korner, H (Professor Heinrich Korner)
ID Code:67935
Year Published:2010
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2011-03-08
Last Modified:2011-05-03
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