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The influence of age on sample size calculation in acute pain trials using morphine consumption as an end point

Citation

Reeves, MD, The influence of age on sample size calculation in acute pain trials using morphine consumption as an end point, Anesthesia and Analgesia, 110, (4) pp. 1186-1190. ISSN 0003-2999 (2010) [Refereed Article]


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Copyright Statement

Copyright © 2010 Lippincott Williams & Wilkins

Official URL: http://www.lww.com/

DOI: doi:10.1213/ANE.0b013e3181d2a8e0

Abstract

BACKGROUND: Many trials in acute postoperative pain use morphine consumption as an end point. Age has been shown to have a significant influence on morphine consumption but is rarely considered in end point analysis. METHODS: Simulation was used to investigate the effect of age on the power of various sample sizes to detect differences in morphine consumption in control and study groups. RESULTS: The sample sizes required for 80% power were approximately twice that predicted by a sample size program when comparing morphine consumption using a t test without adjustment for age. CONCLUSIONS: The model suggests that variations in age have a profound effect on sample size. Researchers may need to account for this to prevent both type 1 and type 2 error.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Anaesthesiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Reeves, MD (Dr Mark Reeves)
ID Code:67820
Year Published:2010
Web of Science® Times Cited:5
Deposited By:Rural Clinical School
Deposited On:2011-03-08
Last Modified:2011-04-12
Downloads:0

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