University of Tasmania
Browse

File(s) not publicly available

Intestinal barrier dysfunction in inflammatory bowel diseases

journal contribution
posted on 2023-05-17, 05:00 authored by McGuckin, MA, Rajaraman Eri, Simms, LA, Florin, TH, Radford-Smith, G
The etiology of human inflammatory bowel diseases (IBDs) is believed to involve inappropriate host responses to the complex commensal microbial flora in the gut, although an altered commensal flora is not completely excluded. A multifunctional cellular and secreted barrier separates the microbial flora from host tissues. Altered function of this barrier remains a major largely unexplored pathway to IBD. Although there is evidence of barrier dysfunction in IBD, it remains unclear whether this is a primary contributor to disease or a consequence of mucosal inflammation. Recent evidence from animal models demonstrating that genetic defects restricted to the epithelium can initiate intestinal inflammation in the presence of normal underlying immunity has refocused attention on epithelial dysfunction in IBD. We review the components of the secreted and cellular barrier, their regulation, including interactions with underlying innate and adaptive immunity, evidence from animal models of the barrier's role in preventing intestinal inflammation, and evidence of barrier dysfunction in both Crohn's disease and ulcerative colitis. Copyright © 2008 Crohn's & Colitis Foundation of America, Inc.

History

Publication title

Inflamm. Bowel Dis

Volume

15

Pagination

100-113

ISSN

1536-4844

Department/School

School of Health Sciences

Publisher

John Wiley & Sons

Place of publication

USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC