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Intestinal barrier dysfunction in inflammatory bowel diseases


McGuckin, MA and Eri, RD and Simms, LA and Florin, TH and Radford-Smith, G, Intestinal barrier dysfunction in inflammatory bowel diseases, Inflamm. Bowel Dis, 15, (1) pp. 100-113. ISSN 1536-4844 (2009) [Refereed Article]

DOI: doi:10.1002/ibd.20539


The etiology of human inflammatory bowel diseases (IBDs) is believed to involve inappropriate host responses to the complex commensal microbial flora in the gut, although an altered commensal flora is not completely excluded. A multifunctional cellular and secreted barrier separates the microbial flora from host tissues. Altered function of this barrier remains a major largely unexplored pathway to IBD. Although there is evidence of barrier dysfunction in IBD, it remains unclear whether this is a primary contributor to disease or a consequence of mucosal inflammation. Recent evidence from animal models demonstrating that genetic defects restricted to the epithelium can initiate intestinal inflammation in the presence of normal underlying immunity has refocused attention on epithelial dysfunction in IBD. We review the components of the secreted and cellular barrier, their regulation, including interactions with underlying innate and adaptive immunity, evidence from animal models of the barrier's role in preventing intestinal inflammation, and evidence of barrier dysfunction in both Crohn's disease and ulcerative colitis. Copyright © 2008 Crohn's & Colitis Foundation of America, Inc.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetic immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Eri, RD (Associate Professor Raj Eri)
ID Code:67802
Year Published:2009
Web of Science® Times Cited:419
Deposited By:Health Sciences A
Deposited On:2011-03-08
Last Modified:2011-03-08

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