eCite Digital Repository

ER stress and the unfolded protein response in intestinal inflammation

Citation

McGuckin, MA and Eri, RD and Das, I and Lourie, R and Florin, TH, ER stress and the unfolded protein response in intestinal inflammation, American Journal of Physiology: Gastrointestinal and Liver Physiology , 298, (6) pp. G820-G832. ISSN 0193-1857 (2010) [Refereed Article]

DOI: doi:10.1152/ajpgi.00063.2010

Abstract

Endoplasmic reticulum (ER) stress is a phenomenon that occurs when excessive protein misfolding occurs during biosynthesis. ER stress triggers a series of signaling and transcriptional events known as the unfolded protein response (UPR). The UPR attempts to restore homeostasis in the ER but if unsuccessful can trigger apoptosis in the stressed cells and local inflammation. Intestinal secretory cells are susceptible to ER stress because they produce large amounts of complex proteins for secretion, most of which are involved in mucosal defense. This review focuses on ER stress in intestinal secretory cells and describes how increased protein misfolding could occur in these cells, the process of degradation of misfolded proteins, the major molecular elements of the UPR pathway, and links between the UPR and inflammation. Evidence is reviewed from mouse models and human inflammatory bowel diseases that ties ER stress and activation of the UPR with intestinal inflammation, and possible therapeutic approaches to ameliorate ER stress are discussed. Copyright © 2010 the American Physiological Society.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genetic Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Digestive System Disorders
Author:Eri, RD (Dr Raj Eri)
ID Code:67788
Year Published:2010
Web of Science® Times Cited:74
Deposited By:Health Sciences A
Deposited On:2011-03-08
Last Modified:2017-04-11
Downloads:0

Repository Staff Only: item control page