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Factors dictating carbene formation at (PNP)Ir

journal contribution
posted on 2023-05-17, 05:00 authored by Brookes, NJ, Whited, MT, Alireza AriafardAlireza Ariafard, Stranger, R, Grubbs, RH, Brian YatesBrian Yates
The mechanistic subtleties involved with the interaction of an amido/bis(phosphine)-supported (PNP)Ir fragment with a series of linear and cyclic ethers have been investigated using density functional theory. Our analysis has revealed the factors dictating reaction direction toward either an iridium-supported carbene or a vinyl ether adduct. The (PNP)Ir structure will allow carbene formation only from accessible carbons α to the ethereal oxygen, such that d electron back-donation from the metal to the carbene ligand is possible. Should these conditions be unavailable, the main competing pathway to form vinyl ether can occur, but only if the (PNP)Ir framework does not sterically interfere with the reacting ether. In situations where steric hindrance prevents unimpeded access to both pathways, the reaction may progress to the initial C-H activation but no further. Our mechanistic analysis is density functional independent and whenever possible confirmed experimentally by trapping intermediate species experimentally. We have also highlighted an interesting systematic error present in the DFT analysis of reactions where steric environment alters considerably within a reaction. © 2010 American Chemical Society.

Funding

Australian Research Council

History

Publication title

Organometallics

Volume

29

Issue

19

Pagination

4239-4250

ISSN

0276-7333

Department/School

School of Natural Sciences

Publisher

Amer Chemical Soc

Place of publication

1155 16Th St, Nw, Washington, USA, Dc, 20036

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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