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Non-invasive characterization of stationary phases in capillary flow systems using scanning capacitively coupled contactless conductivity detection (sC(4)D)

Citation

Connolly, D and Floris, P and Nesterenko, PN and Paull, B, Non-invasive characterization of stationary phases in capillary flow systems using scanning capacitively coupled contactless conductivity detection (sC(4)D), Trends in Analytical Chemistry, 29, (8) pp. 870-884. ISSN 0165-9936 (2010) [Refereed Article]


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DOI: doi:10.1016/j.trac.2010.04.007

Abstract

Capacitively coupled contactless conductivity detection (C4D) has gained interest recently as an elegant new detection method for capillary electrophoresis and, to a lesser extent, liquid chromatography. However, in recent years, the versatility of this non-invasive detection system for research in materials and separation science has been demonstrated through non-traditional applications, mostly using scanning mode (sC4D). This involves the precise measurement of local differences in the conductive response of stationary phases housed within capillary columns. sC4D permits physical and chemical interrogation of stationary phases in capillary columns and microfluidic chips, with potential use in liquid and gas chromatography, capillary-zone electrophoresis or electrochromatography. sC4D also allows evaluation of chemically-modified surfaces to optimize procedures, coverage and chemical or biochemical activity. This review critically summarizes these developments and highlights the potential for widespread application of sC4D, beyond that of simple on-capillary detection.

Item Details

Item Type:Refereed Article
Keywords:Capillary column; Capillary electrophoresis; Capillary-flow reactor; Liquid chromatography; Microfluidic chip; Monolithic material; Non-invasive analysis; Scanning coupled contactless conductivity detection; Stationary phase; Surface modification
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Analytical Spectrometry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Nesterenko, PN (Professor Pavel Nesterenko)
Author:Paull, B (Professor Brett Paull)
ID Code:67603
Year Published:2010
Web of Science® Times Cited:24
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2011-03-05
Last Modified:2011-08-18
Downloads:0

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