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Nutritional compounds influence tissue factor expression and inflammation of chronic kidney disease patients in vitro

Citation

Shing, CM and Adams, MJ and Fassett, RG and Coombes, JS, Nutritional compounds influence tissue factor expression and inflammation of chronic kidney disease patients in vitro, Nutrition: The International Journal of Applied and Basic Nutritional Sciences, 27, (9) pp. 967-972. ISSN 0899-9007 (2011) [Refereed Article]


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DOI: doi:10.1016/j.nut.2010.10.014

Abstract

OBJECTIVE: Nutritional compounds that potentially limit inflammation and tissue factor expression may decrease the progression of chronic kidney disease (CKD) and associated cardiovascular disease. This project aimed to determine the effect of curcumin, bovine colostrum, and fish oil on inflammatory cytokine and tissue factor procoagulant activity of peripheral blood mononuclear cells (PBMCs) from patients with CKD before dialysis. METHODS: Peripheral blood mononuclear cells from patients with CKD before dialysis (n = 13) and age- and sex-matched healthy controls (n = 12) were cultured alone and with low and high doses of the nutritional compounds for 24 h. Cells were cultured with and without lipopolysaccharide. Supernatants were analyzed for tumor necrosis factor-, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1, IL-1, C-reactive protein, and tissue factor procoagulant activity. RESULTS: The production of C-reactive protein, monocyte chemoattractant protein-1, IL-6, and IL-1 by PBMCs was inhibited by low- and high-dose fish oil in the CKD group (P < 0.05). Curcumin decreased secretion of IL-6 (P = 0.015) and IL-1 (P = 0.016). Curcumin was more effective than colostrum at decreasing the procoagulant activity of PBMCs in the CKD and control groups (P < 0.019). CONCLUSION: Fish oil decreased inflammatory cytokine secretion from CKD PBMCs. In addition, the beneficial effects of curcumin were demonstrated in decreasing inflammation in vitro, often to a similar magnitude as fish oil.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Anaesthesiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Blood Disorders
Author:Shing, CM (Dr Cecilia Kitic)
Author:Adams, MJ (Dr Murray Adams)
Author:Fassett, RG (Professor Robert Fassett)
Author:Coombes, JS (Associate Professor Jeff Coombes)
ID Code:67302
Year Published:2011
Web of Science® Times Cited:11
Deposited By:Health Sciences A
Deposited On:2011-03-02
Last Modified:2012-04-18
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