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Tocilizumab: a review of its safety and efficacy in rheumatoid arthritis
Citation
Jones, G and Ding, C, Tocilizumab: a review of its safety and efficacy in rheumatoid arthritis, Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 2010, (3) pp. 81-89. ISSN 1179-5441 (2010) [Refereed Article]
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Copyright Statement
This article is available from http://www.la-press.com Copyright © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
Official URL: http://www.la-press.com/tocilizumab-a-review-of-it...
Abstract
Recent years have seen many exciting developments in the treatment of rheumatoid arthritis. Tocilizumab (TCZ) is a
monoclonal
antibody which inhibits the interleukin-6 receptor. After initial studies in Japan, it has been extensively studied in five multicentre
clinical trials. This report summarises the key efficacy and toxicity findings from the major clinical trials. TCZ works quickly
and effectively in rheumatoid arthritis either as monotherapy or in combination with other agents in early disease, DMARD inadequate
responders, seronegative disease and after anti-TNF failure. The toxicity profile is manageable but includes infections (most notably
skin and soft tissue), increases in serum cholesterol, transient decreases in neutrophil count and abnormal liver function tests (especially
in combination with methotrexate). In summary, there is sufficient evidence to make TCZ a first line biologic therapy for rheumatoid
arthritis especially for those who are unable to take methotrexate or who fail anti-TNF therapy.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | clinical trials, rheumatoid, therapy, interleukin-6 |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Rheumatology and arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Jones, G (Professor Graeme Jones) |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| ID Code: | 66888 |
| Year Published: | 2010 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2011-02-17 |
| Last Modified: | 2011-06-10 |
| Downloads: | 632 View Download Statistics |
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